Aims and
Objectives: To scrutinize the evidence of response shift effect on published
quality of life (QOL) studies investigating the patient-reported outcome to
obtain accuracy data as evaluating clinical practice. Background: People may
alter their internal standards, known as response shift, when they experience
changes in their health status. This phenomenon can falsify patient-re- ported
measures, and has gained increasing attention recently in explaining research
paradoxical findings. Nevertheless a rigorous evidence-base about this effect
on cancer patients QOL is lacking. Design: A systematic review was carried out
under adhered to the guideline of the Quality of Reporting of Meta-Analyses. Methods:
A comprehensive search was conducted on seven English and Chinese databases to
identify and collect studies focus on cancer patients QOL. Methodological
quality assessment was performed to assess the strength of evidence. Results:
Using pre-deter- mined keywords, 584 relevant titles were identified.
Eventually 14 papers satisfied the inclusion criteria and entered the quality
assessment stage. All the articles were written in English and published
between 1996 and 2013.A majority of
the studies used the then-test method, which is also known as the retrospective
pretest-posttest design method. The weighted
mean effect size (WMES) was 0.47 (95% CI 0.31 to 0.63). Using data from
the six studies for assessing then-test/pre-test comparison on the outcome
measure fatigue, the WMES was ﹣0.21 (95% CI ﹣0.32 to ﹣0.10). Conclusion: The alternation of
self-internal standard occurs when cancer patients evaluated their QOL over a
period of time. Relevance to clinical practice: This review emphasizes the need
for a more sensitive approach to inspect the clinical impact of response shift
by measuring changes in QOL. Patients’ adaptation to the disease can then be
more precisely acquired.
Cite this paper
Chao, L. , Fan, J. , Chung, F. and Lam, H. (2014). The Effect of Response Shift on Quality of Life among Cancer Patients: A Systematic Review. Open Access Library Journal, 1, e1099. doi: http://dx.doi.org/10.4236/oalib.1101099.
Herber, O.R.,
Schnepp, W. and Rieger, M.A.
(2007) A Systematic Review on the Impact of Leg Ulceration on Patients’
Quality of Life. Health and Quality of
Life Outcomes, 5,
1-12.
Fortin, M.,
Lapointe, L., Hudon, C., et al. (2004) Multimorbidity and Quality of Life in Primary Care: A Systematic
Review. Health and Quality of Life
Outcomes, 2, 1-12.
Berger, A.M., Sankaranarayanan, J.
and Watanabe-Galloway, S. (2007) Current Methodological Approaches to the
Study of Sleep Disturbances and Quality of Life in Adults with Cancer: A
Systematic Review. Psycho Oncology, 16,
401-420. http://dx.doi.org/10.1002/pon.1079
Wiklund, I.
(2004) Assessment of Patient-Reported Outcomes in Clinical Trials: The Example
of Health-Related Quality of Life. Fundamental
and Clinical Pharmacology, 18, 351-363. http://dx.doi.org/10.1111/j.1472-8206.2004.00234.x
Shimozuma, K.,
Imai, H.,
Kuroi, K., et al. (2007) Recent Topics of Health Outcomes Research in Oncology. Breast Cancer, 14, 60-65. http://dx.doi.org/10.2325/jbcs.14.60
Chao, L.F., Zhang, A.L., Liu, H.E., et al. (2009) The Efficacy of Acupoint Stimulation for
the Management of Therapy- Related Adverse Events in Patients with Breast
Cancer: A Systematic Review. Breast Cancer
Research and Treatment, 118, 255-267. http://dx.doi.org/10.1007/s10549-009-0533-8
Johnson, J.R. and Temple, R.
(1985) Food and Drug Administration Requirements for Approval of New Anticancer
Drugs. Cancer Treatment Reports, 69,
1155-1159.
Patrick, D.L., Burke, L.B., Powers, J.H., et
al. (2007) Patient-Reported Outcomes to Support
Medical Product Labeling Claims: FDA Perspective. Value in Health, 10, 125-137. http://dx.doi.org/10.1111/j.1524-4733.2007.00275.x
Med, B. (2006) Guidance for Industry: Patient-Reported
Outcome Measures: Use in Medical Product Development to Support Labeling Claims:
Draft Guidance. Health and Quality of
Life Outcomes, 4, 79-99. http://dx.doi.org/10.1186/1477-7525-4-79
Sprangers, M.A. and Schwartz, C.E. (1999) Integrating Response Shift into Health-Related
Quality of Life Research: A Theoretical Model. Social Science & Medicine, 48, 1507-1515. http://dx.doi.org/10.1016/S0277-9536(99)00045-3
Sprangers, M.A.G., Moinpour, C.M., Moynihan, T.J., Patrick, D.L.
and Revicki, D.A., Clinical Significance Consensus Meeting Group
(2002) Assessing Meaningful Change in Quality of Life over Time: A Users’
Guide for Clinicians. Mayo
Clinic Proceedings, 77, 561-571.
Sprangers, M.A. and Schwartz, C.E. (1999) Integrating Response Shift into
Health-Related Quality of Life Research: A Theoretical Model. Social Science & Medicine, 48,
1507-1515. http://dx.doi.org/10.1016/S0277-9536(99)00045-3
Oort, F.J.
(2005) Using Structural Equation Modeling to Detect Response Shifts and True
Change. Quality of Life Research, 14,
587-598. http://dx.doi.org/10.1007/s11136-004-0830-y
Korfage, I.J.,
de Koning, H.J.,
Habbema, J.D.,
Schroder, F.H.
and Essink-Bot, M.L.
(2007) Side-Effects of Treatment for Localized Prostate Cancer: Are They Valued
Differently by Patients and Healthy Controls? BJU International, 99, 801-806. http://dx.doi.org/10.1111/j.1464-410X.2006.06707.x
Utne, I.,
Miaskowski, C.,
Bjordal, K.,
Paul, S.M.,
Jakobsen, G.
and Rustoen, T.
(2008) The Relationship between Hope and Pain in a Sample of Hospitalized
Oncology Patients. Palliative and Supportive
Care, 6,
327-334. http://dx.doi.org/10.1017/S1478951508000527
Hickok, J.T.,
Morrow, G.R.,
McDonald, S. and Bellg, A.J.
(1996) Frequency and Correlates of Fatigue in Lung Cancer Patients Receiving
Radiation Therapy: Implications for Management. Journal of Pain and Symptom Management, 11, 370-377. http://dx.doi.org/10.1016/0885-3924(96)00008-5
Barclay-Goddard, R.,
Epstein, J.D. and Mayo, N.E.
(2009) Response Shift: A Brief Overview and Proposed Research Priorities. Quality of Life Research, 18,
335-346. http://dx.doi.org/10.1007/s11136-009-9450-x
Schwartz, C.E.,
Bode, R.,
Repucci, N.,
Becker, J.,
Sprangers, M.A.G. and Fayers, P.M.
(2006) The Clinical Significance of Adaptation to Changing Health: A
Meta-Analysis of Response Shift. Quality
of Life Research, 15, 1533-1550. http://dx.doi.org/10.1007/s11136-006-0025-9
Moher, D.,
Cook, D.J., Eastwood, S., Olkin, I., Rennie, D. and Stroup, D.F. (1999) Improving the Quality of Reports of Meta-Analyses
of Randomised Controlled Trials: The QUOROM Statement. Lancet, 354, 1896-1900. http://dx.doi.org/10.1016/S0140-6736(99)04149-5
Rietman, J.S.,
Dijkstra, P.U.,
Hoekstra, H.J.,
Eisma, W.H.,
Szabo, B.G.,
Groothoff, J.W. and Geertzen,
J.H.B.
(2003) Late Morbidity after Treatment of Breast Cancer in Relation to Daily
Activities and Quality of Life: A Systematic Review. European Journal of Surgical Oncology, 29, 229-238. http://dx.doi.org/10.1053/ejso.2002.1403
Chen, S.M.,
Liu, M.F.,
Cook, J.,
Bass, S. and Lo, S.K.
(2009) Sedentary Lifestyle as a Risk Factor for Low Back Pain: A Systematic
Review. International Archives of
Occupational and Environmental Health, 82, 797-806. http://dx.doi.org/10.1007/s00420-009-0410-0
Borenstein, M. and Rothstein, H. (1999) Comprehensive Meta-Analysis: A Computer
Program for Research Synthesis. Version 1.0. 23 [Computer Software], Biostat, Englewood Cliffs.
Egger, M.,
Smith, G.D.,
Schneider, M. and Minder, C.
(1997) Bias in Meta-Analysis Detected by a Simple, Graphical Test. British Medical Journal, 315,
629. http://dx.doi.org/10.1136/bmj.315.7109.629
Sprangers, M.A. and Schwartz, C.E. (1999) The Challenge of Response Shift for
Quality-of-Life-Based Clinical Oncology Research. Annals of Oncology, 10, 747-749. http://dx.doi.org/10.1023/A:1008305523548
Lowy, A. and Bernhard, J. (2004) Quantitative Assessment of Changes in Patients’
Constructs of Quality of Life: An Application of Multilevel Models. Quality of Life Research, 13,
1177-1185. http://dx.doi.org/10.1023/B:QURE.0000037510.17893.d2
Chow, E.,
Chiu, H.,
Doyle, M.,
Hruby, G.,
Holden, L.,
Barnes, E.A.,
Tsao, M.,
Mallia, G., Harris, K. and Danjoux, C.
(2007) Patient Expectation of the Partial Response and Response Shift in Pain
Score. Supportive Cancer Therapy, 4,
110-118. http://dx.doi.org/10.3816/SCT.2007.n.005
Cella, D., Hahn, E.A. and Dineen, K. (2002) Meaningful Change in Cancer-Specific Quality
of Life Scores: Differences between
Improvement and Worsening. Quality of
Life Research, 11, 207-221. http://dx.doi.org/10.1023/A:1015276414526
Thompson-Fawcett, M.W.,
Richard, C.S., O’Connor, B.I.,
Cohen, Z. and McLeod, R.S. (2000) Quality of Life Is Excellent after a
Pelvic Pouch for Colitis-Associated Neoplasia. Diseases of the Colon & Rectum, 43, 1497-1502. http://dx.doi.org/10.1007/BF02236727
Roos, E.J.,
De Graeff, A.,
Van Eijkeren, M.A., Boon, T.A. and
Heintz, A.P.M. (2004) Quality of Life after Pelvic Exenteration. Gynecologic Oncology, 93,
610-614. http://dx.doi.org/10.1016/j.ygyno.2004.03.008
Mayo, N.E., Scott, S.C., Dendukuri, N., Ahmed, S.
and Wood-Dauphinee, S. (2008) Identifying Response Shift Statistically
at the Individual Level. Quality of Life
Research, 17,
627-639. http://dx.doi.org/10.1007/s11136-008-9329-2
Sharpley, C.F.
and Christie, D.R.H. (2006) How I Was Then and How I Am Now: Current and
Retrospective Self- Reports of Anxiety and Depression in Australian
Women with Breast Cancer. Psycho-Oncology, 16, 752-762. http://dx.doi.org/10.1002/pon.1125
Jorngarden, A., Mattsson, E.
and von Essen, L. (2007) Health-Related Quality of Life, Anxiety
and Depression among Adolescents and Young Adults with Cancer: A Prospective
Longitudinal Study. European Journal of
Cancer, 43,
1952-1958. http://dx.doi.org/10.1016/j.ejca.2007.05.031
Westerman, M.J.,
Hak, T.,
Echteld, M.A.,
Groen, H.J.M. and van der Wal, G. (2007) Change in What Matters to Palliative Patients: Eliciting
Information about Adaptation with SEIQoL-DW. Palliative Medicine, 21, 581-586. http://dx.doi.org/10.1177/0269216307081938
Brossart, D.,
Clay, D. and Willson, V.
(2002) Methodological and Statistical Considerations for Threats to Internal Validity
in Pediatric Outcome Data: Response Shift in Self-Report Outcomes. Journal of Pediatric Psychology, 27,
97-107. http://dx.doi.org/10.1093/jpepsy/27.1.97
Ring, L.,
Hofer, S.,
Heuston, F., Harris, D. and O’Boyle, C. (2005) Response Shift Masks the Treatment
Impact on Patient Reported Outcomes (PROs): The Example of Individual Quality of Life in
Edentulous Patients. Health and Quality
of Life Outcomes, 3, 55.
Schwartz, C., Merriman, M., Reed, G. and
Hammes, B.J. (2004) Measuring Patient Treatment Preferences
in End- of-Life
Care Research: Applications for Advance Care Planning Interventions and
Response Shift Research. Journal of
Palliative Medicine, 7, 233-245. http://dx.doi.org/10.1089/109662104773709350
Ahmed, S.,
Mayo, N.,
Wood-Dauphinee, S.,
Hanley, J.A. and Robin Cohen, S. (2004) Response Shift Influenced Estimates of
Change in Health-Related Quality of Life Poststroke. Journal of Clinical Epidemiology, 57, 561-570. http://dx.doi.org/10.1016/j.jclinepi.2003.11.003
Sprangers, M.A.G.
(1996) Response-Shift Bias: A Challenge to the Assessment of Patients’
Quality of Life in Cancer Clinical Trials. Cancer Treatment Reviews, 22,
55-62.
Sprangers, M.A.G., Van Dam, F.S.A.M., Broersen, J., Lodder, L., Wever, L., Visser, M.R.M., Oosterveld, P. and Smets, E.M.A. (1999) Revealing Response Shift in Longitudinal
Research on Fatigue: The Use of the
Thentest Approach. Acta Oncologica, 38,
709-718. http://dx.doi.org/10.1080/028418699432860
Visser, M.,
Smets, E.,
Sprangers, M. and de Haes, H.J.C.J.M.
(2000) How Response Shift May Affect the Measurement of Change in Fatigue. Journal of Pain and Symptom Management, 20,
12-18. http://dx.doi.org/10.1016/S0885-3924(00)00148-2
Jansen, S.,
Stiggelbout, A.,
Nooij, M., Noordijk, E.M.
and Kievit, J. (2000) Response Shift in Quality of Life Measurement
in Early-Stage Breast Cancer Patients Undergoing Radiotherapy. Quality of Life Research, 9,
603-615. http://dx.doi.org/10.1023/A:1008928617014
Bernhard, J.,
Lowy, A.,
Maibach, R. and Hürny, C. (2001) Response Shift in the Perception of Health for Utility Evaluation.
An Explorative Investigation. European
Journal of Cancer, 37, 1729-1735. http://dx.doi.org/10.1016/S0959-8049(01)00196-4
Visser, M.R.,
Oort, F.J. and Sprangers, M.A. (2005) Methods to Detect Response Shift in
Quality of Life Data: A Convergent Validity Study. Quality of Life Research, 14, 629-639. http://dx.doi.org/10.1007/s11136-004-2577-x
Rees, J.,
Clarke, M.,
Waldron, D., O’Boyle,
C.,
Ewings, P.
and MacDonagh, R.P.
(2005) The Measurement of Response Shift in Patients with Advanced Prostate
Cancer and Their Partners. Health and
Quality of Life Outcomes, 3, 21.
Korfage, I.,
de Koning, H. and Essink-Bot, M. (2007) Response Shift Due to Diagnosis and
Primary Treatment of Localized Prostate Cancer: A Then-Test and a Vignette
Study. Quality of Life Research, 16,
1627-1634. http://dx.doi.org/10.1007/s11136-007-9265-6
Andrykowski, M.A.,
Donovan, K.A. and Jacobsen, P.B. (2009) Magnitude and Correlates of Response
Shift in Fatigue Ratings in Women Undergoing Adjuvant Therapy for Breast
Cancer. Journal of Pain and Symptom
Management, 37,
341-351. http://dx.doi.org/10.1016/j.jpainsymman.2008.03.015
Lepore, S.J. and Eton, D.T.
(2000) Response Shifts in Prostate Cancer Patients: An Evaluation of Suppressor
and Buffer Models. In: Adaptation
to Changing Health: Response
Shift in Quality-of-Life Research, Washington DC, 37-51.
Hagedoorn, M.,
Sneeuw, K. and Aaronson, N. (2002) Changes in Physical Functioning and
Quality of Life in Patients with Cancer: Response Shift and Relative Evaluation of One’s
Condition. Journal of Clinical Epidemiology, 55,
176- 183. http://dx.doi.org/10.1016/S0895-4356(01)00438-3
Oort, F.J.,
Visser, M.R.M. and Sprangers, M.A.G. (2005) An Application of Structural Equation
Modeling to Detect Response Shifts and True Change in Quality of Life Data from
Cancer Patients Undergoing Invasive Surgery. Quality of Life Research, 14, 599-609. http://dx.doi.org/10.1007/s11136-004-0831-x
Sharpe, L.,
Butow, P.,
Smith, C.,
McConnell, D. and Clarke, S.
(2005) Changes in Quality of Life in Patients with Advanced Cancer: Evidence of
Response Shift and Response Restriction. Journal
of Psychosomatic Research, 58, 497- 504. http://dx.doi.org/10.1016/j.jpsychores.2005.02.017
Moons, P.,
Marquet, K.,
Budts, W. and De Geest, S. (2004) Validity, Reliability and Responsiveness
of the “Schedule
for the Evaluation of Individual Quality of
Life—Direct Weighting” (SEIQoL-DW) in Congenital Heart Disease. Health and Quality of Life Outcomes, 2,
27. http://dx.doi.org/10.1186/1477-7525-2-27
Campbell, S. and Whyte, F.
(1999) The Quality of Life of Cancer Patients Participating in Phase I Clinical
Trials Using SEIQoL-DW. Journal of
Advanced Nursing, 30, 335-343. http://dx.doi.org/10.1046/j.1365-2648.1999.01079.x
Neudert, C.,
Wasner, M. and Borasio, G.D.
(2001) Patients’
Assessment of Quality of Life Instruments: A Randomised Study of SIP, SF-36 and
SEIQoL-DW in Patients with Amyotrophic Lateral Sclerosis. Journal of the Neurological Sciences, 191,
103-109. http://dx.doi.org/10.1016/S0022-510X(01)00612-8
Schwartz, C.E., Bode, R.,
Repucci, N.,
Becker, J.,
Sprangers, M.A. and Fayers, P.M.
(2006) The Clinical Significance of Adaptation to Changing Health: A
Meta-Analysis of Response Shift. Quality
of Life Research, 15, 1533-1550. http://dx.doi.org/10.1007/s11136-006-0025-9
