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Mar 09, 2018Open    AccessArticle

Screening of Single Nucleotide Polymorphism in CD95 (APO-1/FAS) Promoter Region (G-1377A) in Children with Acute Leukemia

Dilara Fatma Akin Bali, Didem Torun Ozkan, Ahmet Emin Kurekci, Nejat Akar
CD95 is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in down regulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism (SNP) resulting in guanine-to-adenine (G > A) transition in the CD95 promoter region (position ﹣1377) is thought to reduce stimulatory protein 1 (SP1) transcription factor binding and decrease CD95 express

Feb 26, 2018Open    AccessArticle

Prevalence and Morphological Types of Anaemia among Children Under-Five Years in the Volta Regional Hospital of Ghana

Joseph Adu-Amankwaah, Emmanuel Alote Allotey, David Annor Kwasie, Innocent Afeke, Patrick Kwasi Owiafe, Paul Chukwuemeka Adiukwu, Orish Verner Ndudiri
Background: This study aimed at determining the prevalence and morphological types of anaemia, among children under-five years, who had full blood count (FBC) investigation done at the laboratory of the Volta regional hospital. Methodology: This was a retrospective study of archival FBC test results data for children below 5 years in the laboratory, between1st July to 31

Feb 23, 2018Open    AccessArticle

Higher Complication Rate Following Hip Fractures in Uremic Patients Undergoing Maintenance Hemodialysis: A Cohort Study

Yi-Hsun Yu, Yung-Heng Hsu, Ying-Chao Chou, I-Chuan Tseng, Wen-Lin Yeh, Chi-Chung Wu
The current study retrospectively reviewed the surgical outcomes following hip fractures in uremic patients undergoing long-term hemodialysis and compared the results with those of geriatric patients with osteoporotic hip fractures during 1-year period. Thirteen complications occurred among the 21 uremic patients who underwent surgical intervention for a hip fra

Jan 29, 2018Open    AccessArticle

The Investigation of the Apoptose Structural Effects and Mechanism in Leukemic Cells of Sirt1 Inhibitor Sirtinol

Dilara Fatma Akin, Mine Mumcuoglu, Didem Torun Ozkan, Nejat Akar, Ahmet Emin Kurekci
Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein. It has been suggested to modulate p53-dependent functions including DNA damage-induced cell death. Sirtuins are nicotinamide adenine dinucleotide dependent class III histone deacetylase proteins that play a crucial role in several cellular processes, including DNA repair, apoptosis, and lifespan. In this study, we investigated the relationship between sir

Aug 11, 2017Open    AccessArticle

Platelet Characterization in Helicobacter Pylori Patients

Sahwa Ahmed Ali, Nasr Eldeen Ali Mohammed Gaufri
Background: Recently the data has been increasing on the association between Helicobacter pylori infection and thrombocytopenia characterization specifically in developing countries. Objective: This study was aimed to evaluate platelet count and platelet indices in Helicobacter pylori infected

Jun 22, 2017Open    AccessArticle

Effects of Cigarette Smoking on White Blood Cells Count and von Willebrand Factor Levels in Male Smokers in Khartoum State

Roaa Babikir Ahmed, Mahdi H. A. Abdalla
Background: Tobacco cigarette smoking is one of the major leading causes of death and essential public health challenge in world over. Elevated von Willebrand factor (vWF) concentrations are associated with an increased risk of ischemic heart disease. High total leukocyte count can promote cardiovascular diseases through multiple pathologic mechanisms, and has been considered as an independent predictor of

Apr 12, 2017Open    AccessArticle

Association of Fibrinogen, Erythrocyte Sedimentation Rate and C-Reactive Protein Levels with Rheumatoid Arthritis

Mohamed Babikir Omer Babikir, Nasr Eldeen Ali Mohammed Gaufri
Background: Many studies were made the association between the extent of the inflammatory response, increase fibrinogen level and hypercoagulability in rheumatoid arthritis. The current study aims to the investigation and finds the association of the fibrinogen, ESR and CRP levels in Sudanese patients with rheumatoid arthritis. Material and Methods: This is a case-control study, conducted at M

Mar 31, 2017Open    AccessArticle

Seroprevalence of Hepatitis B among Blood Donors in Mbuji-Mayi, “Case of Dipumba General Hospital” (DRC)

Ciamala Mukendi Paul, Kanyiki Katala Moise, Banza Ndala Deca Blood, Ntumba Mukendi Kennedy, Jean Mukendi Mukendi Réne, Kolela Kolela Alain, Kaya Tompa Brigitte, Gabriel Mbuyi Lubemba, Bukasa Lumbayi Laurent, Kabamba Nzaji Michel
Seroprevalence among blood donors is a major public health problem, both in developed and developing countries, in its magnitude. The aim of this study was to determine the seroprevalence of hepatitis B in blood donors. This is a descriptive study carried out in the city of Mbuji-Mayi at the General Hospital of Dipumba in blood donors (family, volunteer and remunerated) recorded from 01/to31/December 2016; the data were collected

Mar 28, 2017Open    AccessArticle

Seroprevalence of Hepatitis B Virus Infection (HBsAg) in Rural Blood Donors, Moba, Tanganyika Province, Democratic Republic of Congo (2014 to 2016)

Bukasa Héman Kabemba, Ebondo Patrick Kasendue, Muteba André Shiku, Tchoni Savant Mukena, Tshinkobo Chicco Kasolva, Nsomue Gentil Kabingie, Kabiswe Joelle Pungue, Tshite John Kitengie
Blood transfusion is a salutary practice in modern medicine, but it carries a high risk of transmission of transfusion transmitted infections (TTIs), especially in developing countries. The objective of this study is to determine the seroprevalence of viral hepatitis B among blood donors. This is a retrospective and descriptive cross-sectional study of the period from 2014 to 2016 at the Katele Health Reference Center (Moba, DR. C

Feb 06, 2017Open    AccessArticle

Estimation and Assessment of D-Dimer Levels in Sudanese Patients with Pulmonary Tuberculosis

Sahar Abdelhameed Abass Alhassan, Nasr Eldeen Ali Mohammed Gaufri
Background: The association between pulmonary tuberculosis and a hypercoagulable state is well documented. An increased D-dimer level is linked with increasing the mortality of pulmonary tuberculosis infection. Objective: The current study aimed to the estimation and assessment of the D-dimer levels in Sudanese patients with pulmonary tuberculosis. Material and Methods: This is a case control study that was conducted during March