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Oct 31, 2023Open Access
Malaria is a parasitic disease caused by the protozoan parasites Plasmodium species, and usually transmitted through the bite of a female Anopheles species mosquito. Plasmodium falciparum is regarded as the most lethal of the Plasmodium species and most efforts are geared towards its control. Hitherto, with no available vaccines, an antimalarial drug such as Chloroquine was the main stay in the clinical management of uncomplicated P. falciparum malari...
Aug 18, 2023Open Access
The application of biotechnology in drug discovery has been discovered to be a promising and resourceful approach for the discovery of novel therapeutic candidates that comes with less time and cost than the traditional ways of drug discovery. This has additionally endowed researchers with the necessary understanding of diseases, which offers exceptional methods for treating patients. Additionally, diagnosis and treatment are becoming increasingly intertwined with the help of biotechnology. Toda...
Jun 28, 2023Open Access
We performed aurora kinase gene expression analysis, in combination with FISH and micronucleus test, in buccal mucosa cells isolated from agricultural workers to better understand the dynamics of genomic instability in these groups of professionals. Two out of a total of 97 agricultural workers who consented to participate in the study (39 men and 58 women) reported a history of cancer based on a previously applied questionnaire. The participants were 28.4 years on average and were categorized i...
Aug 19, 2022Open Access
Blotting is a classical technique for detecting macro-biomolecules of interest from a mixture of molecules. The technique is generally composed of four steps: 1) gel electrophoresis-based separation of molecules, 2) blotting (transfer and immobilization) of separated molecules from the gel onto the membrane, 3) specific hybridization of probes to target molecules on the membrane, and 4) visualization of the probe/target molecule complex. The present article briefly introduces blotting techniques...
Jun 10, 2022Open Access
Agroforestry systems (SAFs) are an alternative for sustainable development as they enable the recovery of degraded areas and reduce deforestation, contributing to breaking the cycle of traditional family farming, so common in the Amazon region, which enables the recovery of soils, the increase of organic matter and soil fertility. Cocoa beans are grown and fermented in SAFs. According to the research, the significant appearance of endophytic microorganisms such as fungi in the cocoa bean can ben...
Apr 24, 2022Open Access
The speckle noise is considered one of the main causes of degradation in ultrasound image quality. Many despeckling filters have been proposed, which are always making a trade-off between noise suppression and loss of information. A class of despeckling methods based Non-Local Means (NLM) algorithm is known to efficiently preserve the edges and all fine details of an image while reducing the noise. The core idea of NLM filter is to estimate the denoised pixel by performing a weighted average of ...
Nov 08, 2021Open Access
Four hybrids between Serpocaulon species have been described, one of them S. × sessilipinnum was the only known hybrid between two different clades proposed by Smith et al. In this work, a new hybrid S. × orosiense is described, being the second known hybrid between clades: 1) Serpocaulon loriceum and 2) S. fraxinifolium. The detailed study of the intermediate morphology of the characters of the new taxon and their progenitors were made by ...
Jul 29, 2021Open Access
According to the technical application, therapeutic mechanism and application prospect of therapeutic antibodies are discussed from the research and development of therapeutic antibodies to their application technology. Also, following is a list of some disadvantages of the drug. May this article shall lead perspective in the next section.
Jun 28, 2021Open Access
Wnt5a is a representative protein ligand that activates a beta catenin independent pathway in Wnt signaling in cancer progression and spread in the palmitoylated form. So that its synthesis is augmented through promotion of its gene transcription in the malignant cells. Cisplatin is an important chemotherapeutic drug used in treatment of different types of advanced cancer. However, its usage is limited due to severe dose-limiting side effects, due to the lack of targeting therapy of cisplatin. O...
Apr 20, 2021Open Access
The Vespa mandarinia disaster has been a problem all over the world. In the prevention and control of Vespa mandarinia, the efficiency is often low and a lot of social resources are wasted because of the inability to effectively predict the spread of Vespa mandarinia. Therefore, this paper proposes a propagation model based on independent cascade. Based on the traditional propagation model, the habit factor and propagation index are added, which makes the habit and reproduction of wasps fully co...
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