Hematological and Biochemical Evaluation of Teucrium Polium in Albino Rats

This study evaluates the effect of acute (24 h) and subacute (3 weeks) treatment of the Teucrium polium decoction on liver and kidney functions and hematological parameters in rats. The toxicity study with this decoction did not produce mortality. No marked adverse alterations were observed in hematological and biochemical parameters during acute toxicity. In the subacute toxicity studies, red blood cells counts, Hemoglobin (Hb) and Packed Cell Volume (PVC) insignificantly decreased. However, other blood indices, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC) were not changed. There was significant (p<0.001) increase in white blood cells. Serum glucose level change was insignificant, while the level of serum cholesterol and triglycerides were significantly (p<0.001) reduced. The Activity of Serum Transaminases (ALT and AST) showed non significant changes, urea, uric acid and creatinine levels were found non significant changes. In conclusion the statistical analysis of our results indicates that treatment with T. polium did not cause any attension that might suggest the presence of pathological damage at the dose investigation.