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慢性肾脏病肾组织炎症信号通路p38MAPK的调节机制及中药的干预作用

Keywords: 慢性肾脏病,中药,p38丝裂原活化蛋白激酶,信号通路

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Abstract:

肾组织的炎症反应及其相关的组织损伤(如肾小球硬化和肾间质纤维化)是导致慢性肾脏病(chronickidneydisease,CKD)进展至终末期肾病的重要因素。其中,p38丝裂原活化蛋白激酶(mitogen-activatedproteinkinase,MAPK)信号通路能够调控多种核转录因子的表达和生物活性,还可以影响下游炎症介质的合成,并参与炎症细胞的活化,在肾脏疾病炎症损伤中发挥着重要的作用。某些单味中药及其提取物(如大黄素、黄连素)以及一些中药复方(如益肾活血汤)可以通过调节p38MAPK信号通路而影响肾组织内炎症反应,从而,减轻肾小球、肾间质炎症损伤。

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