Background: There is a need to do ABO incompatible kidney transplantation
in a country like India where deceased donor transplantation is not common.
More than 90% transplantations are done with living donors. Although short term
results have been reported from 4 centers, there is paucity of data on long
term follow-up of such patients. Methods: The data of 18 patients who had
undergone ABO incompatible transplantation exceeding a follow-up of 12 months
up to 66 months were analyzed. It was compared with the data of compatible
kidney transplantation during the same period. Results: In both the groups,
there was a similar incidence of urinary tract infection and gastroenteritis
with complete recovery. Tuberculosis was successfully treated in 2 patients who
had undergone ABO incompatible transplantation. The graft function was
excellent with an average follow-up period of 38.2 months. There was no patient
mortality during the follow-up period. Conclusion: The long term outcome of ABO
incompatible kidney transplantation is similar to compatible kidney
transplantation despite the increased incidence of short term complications.
References
[1]
Wilpert, J., Fischer, K., Pisarski, P., Wiech, T.,
Daskalakis, M., Ziegler, A., Neumann-Haefelin, E., Drognitz, O., Emmerich, F.,
Walz, G. and Geyer, M. (2010) Long-Term Outcome of ABO-Incompatible Living
Donor Kidney Transplantation Based on Antigen-Specific Desensitization. An Observational
Comparative Analysis. Nephrology Dialysis Transplantation, 25, 3778-3786. http://dx.doi.org/10.1093/ndt/gfq229
[2]
Montgomery, J., Berger, J.,
Warren, D., James, N., Montgomery, R. and Segev, D. (2012) Outcomes of
ABO-Incom- patible Kidney Transplantation in the United States. Transplantation,
1. http://dx.doi.org/10.1097/TP.0b013e318245b2af
[3]
Uchida,
J., Kuwabara, N., Machida, Y., Iwai, T., Naganuma, T., Kumada, N. and Nakatani,
T. (2012) Excellent Outcomes of ABO-Incompatible Kidney Transplantation: A
Single-Center Experience. Transplantation Proceedings, 44, 204-209. http://dx.doi.org/10.1016/j.transproceed.2011.11.006
[4]
Oettl, T., Halter, J.,
Bachmann, A., Guerke, L., Infanti, L., Oertli, D., Mihatsch, M., Gratwohl, A.,
Steiger, J. and Dickenmann, M. (2008) ABO Blood Group-Incompatible Living Donor
Kidney Transplantation: A Prospective, Single-Centre Analysis Including Serial
Protocol Biopsies. Nephrology Dialysis Transplantation, 24, 298-303. http://dx.doi.org/10.1093/ndt/gfn478
Bhadauria,
D., Goel, A., Kaul, A., Sharma, R., Gupta, A., Ruhela, V., Gupta, A., Vardhan,
H. and Prasad, N. (2015) Cryptosporidium Infection after Renal Transplantation in
an Endemic Area. Transplant Infectious Disease, 17, 48-55. http://dx.doi.org/10.1111/tid.12336
[8]
John,
G., Shankar, V., Abraham, A., Mukundan, U., Thomas, P. and Jacob, C. (2001)
Risk Factors for Post-Transplant Tuberculosis. Kidney International, 60, 1148-1153. http://dx.doi.org/10.1046/j.1523-1755.2001.0600031148.x
[9]
Iqbal, T., Naqvi, R. and Akhter, S.F. (2010) Frequency of Urinary Tract Infection in Renal Transplant Recipients
and Effect on Graft Function. Journal of Pakistan Medical Association, 60, 826-829.
[10]
Shin, M. and Kim, S. (2011) ABO Incompatible Kidney Transplantation—Current Status
and Uncertainties. Journal of Transplantation, 2011, 1-11. http://dx.doi.org/10.1155/2011/970421
[11]
Habicht,
A., Broker, V., Blume, C., Lorenzen, J., Schiffer, M., Richter, N., Klempnauer,
J., Haller, H., Lehner, F. and Schwarz, A. (2011) Increase of Infectious Complications
in ABO-Incompatible Kidney Transplant Recipients—A Single Centre Experience. Nephrology
Dialysis Transplantation, 26, 4124-4131. http://dx.doi.org/10.1093/ndt/gfr215
[12]
Ravichandran, R., Kanakaraj, A.,
Shakthivel, A. and Srinivas, C. (2012) ABO Incompatible Kidney Transplantation— A Single
Center Experience. Indian Journal of Transplantation,
6, 103-106. http://dx.doi.org/10.1016/j.ijt.2012.10.002
[13]
Virani,
Z., Bhagat, A., Rajput, P., Shah, B., Pagar, S., Bala, S. and Dawane, V. (2014)
Our Initial Experience with ABO-Incompatible Transplant. Indian Journal of
Transplantation, 8, 132-133. http://dx.doi.org/10.1016/j.ijt.2014.12.021
[14]
Jha, P.K., Bansal, S.B., Sethi, S.K., et al. (2015) ABO-Incompatible Renal
Transplantation in Developing World— Crossing the Immunological (and Mental)
Barrier. Indian Journal of Nephrology, 26, 113-118. http://www.indianjnephrol.org/preprintarticle.asp?id=159557
[15]
Jha, V. (2013)
Current Status of End-Stage Renal Disease Care in India and Pakistan. Kidney
International Supplements, 3, 157-160. http://dx.doi.org/10.1038/kisup.2013.3
[16]
Tobian,
A., Shirey, R., Montgomery, R., Cai, W., Haas, M., Ness, P. and King, K. (2010)
ABO Antibody Titer and Risk of Antibody-Mediated Rejection in ABO-Incompatible
Renal Transplantation. American Journal of Transplantation, 10, 1247-1253. http://dx.doi.org/10.1111/j.1600-6143.2010.03103.x
