During prolonged exercise, fatty acids are mobilized from triglycerides
(TG) and become an important energy source. But excess accumulation of TG in
different tissues causes abnormalities in humans. Role of high fat diet in the
distribution of TG is well established but the role of mixed dietary fat is not
clear. In our study, exercised Swiss Albino mice were subjected to feed high
fat diet and mixed fat diet (Saturated Unsaturated fat enriched diet) for the
period of four weeks to show the effect on average body weight, liver, adipose
tissue and gastrocnemius muscles and the accumulation of their triglycerides
(TG) content. This study showed that both diets had little or no effect on
average body weight, epididymal adipose tissue weight and liver TG but
decreased liver weight. Here another remarkable feature was that high fat diet
significantly reduced the accumulation of TG in epididymal adipose tissue in
comparison with mixed fat diet. The author demonstrated that mixed fat diet induced
accumulation of TG in gastrocnemius skeletal muscles of exercised mice but
decreased gastrocnemius skeletal muscles weight. Further research is required
to clarify these phenomena.
Cite this paper
Rahman, S. S. , Ali, M. A. and Rahman, M. N. (2015). Effects of Mixed Dietary Fats on the Distribution of Triglycerides in Different Tissues of Exercised Trained Swiss Albino Mice. Open Access Library Journal, 2, e2113. doi: http://dx.doi.org/10.4236/oalib.1102113.
Spriet, L.L. and Watt, M.J.
(2003) Regulatory Mechanisms in the Interaction between Carbohydrate and Lipid
Oxidation during Exercise. Acta Physiologica Scandinavica, 178, 443-452. http://dx.doi.org/10.1046/j.1365-201X.2003.01152.x
Piscitelli, F., Carta, G., Bisogno, T., Murru, E. and Cordeddu, L. (2011) Effect of Dietary Krill Oil Supplementation on the Endocannabinoidome
of Metabolically Relevant Tissues from High Fat-Fed Mice. Nutrition & Metabolism, 8, 51. http://dx.doi.org/10.1186/1743-7075-8-51
Tandy, S., Chung, R.W., Wat, E., Kamili, A. and Berge, K. (2009) Dietary Krill Oil
Supplementation Reduces Hepatic Steatosis, Glycemia, and Hypercholesterolemia in
High-Fat-Fed Mice. Journal of
Agricultural and Food Chemistry, 57, 9339-9345. http://dx.doi.org/10.1021/jf9016042
Bracco, E.F., Torbay, N., Geiebter, A., Stewart, I., Seylar, J. and Hashim, S.A. (1980) Insulin Increases Body Fat with Control of Food Intake and Physical
Activity. Alimentary Nutrition &
Metabolism, l, 234.
Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., et al. (2008) FSP27 Contributes to Efficient
Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular
Lipid Droplets. Journal of Clinical Investigation, 118, 2808-2821.
Hotamisligil, G.S., Budavari, A., Murray, D. and Spiegelman, B.M. (1994) Reduced Tyrosine
Kinase Activity of the Insulin Receptor in Obesity-Diabetes: Central Role of Tumor
Necrosis Factor-Alpha. Journal of Clinical Investigation, 94, 1543-1549. http://dx.doi.org/10.1172/JCI117495
Hotamisligil, G.S., Shargill, N.S. and Spiegelman, B.M. (1993) Adipose Expression of Tumor Necrosis Factor-Alpha: Direct
Role in Obesity-Linked Insulin Resistance. Science, 259, 87-91. http://dx.doi.org/10.1126/science.7678183
Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A. and Luzi, L. (1999) Intramyocellular
Triglyceride Content Is a Determinant of in
Vivo Insulin Resistance in Humans: A 1H-13C Nuclear Magnetic Resonance
Spectroscopy Assessment in Offspring of Type 2 Diabetic Parents. Diabetes, 48, 1600-1606. http://dx.doi.org/10.2337/diabetes.48.8.1600
Kunesova, M.,
Braunerova, R., Hlavaty, P., Tvrzicka, E. and Stankova, B. (2006) The Influence of n-3 Polyunsaturated Fatty Acids and
Very Low Calorie Diet during a Short-Term Weight Reducing Regimen on Weight
Loss and Serum Fatty Acid Composition in Severely Obese Women. Physiological Research, 55, 63-72.
Mori, T.A., Bao, D.Q., Burke, V., Puddey, I.B. and Watts, G.F. (1999)
Dietary Fish as a Major Component of a Weight-Loss Diet: Effect on Serum
Lipids, Glucose, and Insulin Metabolism in Overweight Hypertensive Subjects. The American Journal of Clinical Nutrition,
70, 817-825.
Rossmeisl, M., Macek
Jilkova, Z., Kuda, O., Jelenik, T., Medrikova, D., et al. (2012)
Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in
Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids. PLoS ONE, 7, e38834. http://dx.doi.org/10.1371/journal.pone.0038834
Harkins, R.W. and Sarett, H.P. (1968) Nutritional Evaluation
of Medium-Chain Triglycerides in the Rat. Journal
of the American Oil Chemists’ Society, 45, 26-30. http://dx.doi.org/10.1007/BF02679041
Kaunitz, H., Slanetz, C.A., Johnson, R.E., Babayan, V.K. and Barsky, G. (1958)
Relation of Saturated, Medium- and Longchain Triglycerides to Growth, Appetite,
Thirst and Weight Maintenance Requirements. Journal
of Nutrition, 64, 13-24.
Harris, R.B. (1994)
Factors Influencing Energy Intake of Rats Fed either a High-Fat or a Fat Mimetic
Diet. International Journal of Obesity
and Related Metabolic Disorders, 18, 632-640.
Altunkaynak, Z. (2005) Effects of High
Fat Diet Induced Obesity on Female Rat Livers (a Histological Study). European Journal of General Medicine, 2, 100-109.
Straczkowski, M., Kowalska, I., Dzienis-Straczkowska, S., Kinalski, M., Górski, J. and
Kinalska, I. (2001) The Effect of Exercise Training on Glucose Tolerance
and Skeletal Muscle Triacylglycerol Content in Rats Fed with a High-Fat Diet. Diabetes & Metabolism, 27, 19-23.
Yasari, S., Paquette, A., Charbonneau, A., Gauthier, M.S., Savard, R. and Lavoie, J.M. (2006) Effects of Ingesting a High-Fat Diet upon
Exercise-Training Cease Fat Accretion in the Liver and Adipose Tissue of Rats. Applied Physiology, Nutrition, and Metabolism,
31, 367-375. http://dx.doi.org/10.1139/h06-032
Yasari, S., Dufresne, E., Prud’homme, D. and Lavoie, J.M.
(2007) Effect of the Detraining Status on High-Fat
Diet Induced Fat Accumulation in the Adipose Tissue and Liver in Female Rats. Physiology & Behavior, 91, 281-289. http://dx.doi.org/10.1016/j.physbeh.2007.03.012
Corcoran,
M.P., Lamon-Fava, S. and Fielding, R.A. (2007) Skeletal Muscle Lipid Deposition and Insulin Resistance:
Effect of Dietary Fatty Acids and Exercise1,2,3. The American Journal of Clinical Nutrition, 85, 662-677.
