Background: The
association between pulmonary tuberculosis and a hypercoagulable state is well documented. An increased D-dimer level
is linked with increasing the mortality of pulmonary
tuberculosis infection. Objective: The current study aimed to the estimation and assessment of the D-dimer
levels in Sudanese patients with pulmonary tuberculosis. Material and Methods: This
is a case control study that was conducted during March 2016 at Faculty of Medical Laboratory Sciences,
Alneelain University, Khartoum, Sudan. A total of 70 subjects were included in this
study, classified into two groups.
The first group consists of 40 subjects, among which 30 (75%) were males and 10 (25%) were female; their mean age is 32.3 years
classified as patients group; of other 30 normal healthy subjects, 15 (50%)
were female and 15 (50%)
were males; their mean age was 33.1 years in the second group as normal control
group. The platelet poor plasma was prepared immediately from citrated blood by
centrifuging at 2000 rpm for 15 minutes. The data were collected by structured interview and questionnaire, and then analyzed by using a
computer program statistical package for social sciences (SPSS) version 21. The D-dimer levels were
measured using immunometric assay (Nyco Card READER II). Result: The present study found
that the D-dimer levels were statistically significantly higher in pulmonary tuberculosis patients compared
to the normal healthy control groups (Mean ± SD 0.82 ± 0.54 vs. 0.33 ± 0.13 with p value 0.00). Conclusion: This study
showed that Sudanese patient with pulmonary tuberculosis has increased the
plasma D-dimer level, and this abnormality could be prone to Deep Vein Thrombosis (DVT).
Cite this paper
Alhassan, S. A. A. and Gaufri, N. E. A. M. (2017). Estimation and Assessment of D-Dimer Levels in Sudanese Patients with Pulmonary Tuberculosis. Open Access Library Journal, 4, e3211. doi: http://dx.doi.org/10.4236/oalib.1103211.
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