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Vitamin B12 Deficiency in Resistant Schizophrenia in Tropics

DOI: 10.4236/oalib.1103400, PP. 1-4

Subject Areas: Psychiatry & Psychology

Keywords: B12 Deficiency, Schizophrenia, Hyperhomocysteinemia

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Abstract

Vitamin B12 deficiency and hyperhomocysteinemia are common in tropical developing countries. In prevalence study, among Indian population by Yajnik and colleagues, 67% of men had low vitamin B12 concentration and 58% had hyperhomocysteinemia [1]. Here, we report two patients with vitamin B12 deficiency presented with symptoms of schizophrenia and required very high doses of antipsychotic medication surprisingly without any anticipated extra pyramidal side effects. The initial requirement of high dose of antipsychotic medication significantly came down after adding parenteral cobalamin supplementation.

Cite this paper

Kumanan, T. , Thomas, N. and Pirasath, S. (2017). Vitamin B12 Deficiency in Resistant Schizophrenia in Tropics. Open Access Library Journal, 4, e3400. doi: http://dx.doi.org/10.4236/oalib.1103400.

References

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[5]  Shulman, R. (1967) A Survey of Vitamin B12 Deficiency in an Elderly Psychiatric Population. British Journal of Psychiatry, 113, 241-251. https://doi.org/10.1192/bjp.113.496.241
[6]  Bolander-Gouaille, C. and Bottiglieri, T. (2007) Homocysteine Metabolism. In: Bo-lander-Gouaille, C. and Bottiglieri, T., Eds., Homocysteine Related Vitamins and Neuropsychiatric Disorders, Springer-Verlag, France, 21-35. https://doi.org/10.1007/978-2-287-69375-5_3
[7]  Masalha, R., Chudakov, B., Muhamad, M., Rudoy, I., Volkov, I. and Wirguin, I. (2001) Cobalamin-Responsive Psychosis as the Sole Manifestation of Vitamin B12 Deficiency. Israel Medical Association Journal, 3, 701-703.

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