Ionic liquid based
ultrasonic-assisted extraction (ILUAE) was successfully applied to extract
Oleanolic acid (OA)
from grape seeds. Different kinds of 1-alkyl-3-methylimidazolium ionic liquids
with different kinds of cations and anions were studied and
1-butyl-3-methylimidazolium chloride ([C4mim]Cl) solution was
selected as extractants. The optimal conditions of ILUAE were determined by
single factor experiments and Box-Behnken design as follows: [C4mim]Cl
concentration of 0.7 mol/L,
extraction time of 4 h,
liquid-solid ratio of 15:1 mL/g,
ultrasonic power of 195 W, the
ultrasonication time of 13 min,
and extraction temperature of 48℃·min. The extraction yield of
OA was 13.4 mg/g, which is well in close agreement
with the value predicted by the model. Compared with the regular
ultrasonic-assisted extraction (UAE), the proposed approach exhibited 1.64
times higher efficiency, which indicated that ILUAE has a broad prospect for
sample preparation of the bioactive compounds.
Cite this paper
Zhang, X. , Li, X. , He, Q. , Zhang, B. and Zheng, X. (2017). Ionic Liquid Based Ultrasonic-Assisted Extraction of Oleanolic Acid from Grape Seeds. Open Access Library Journal, 4, e4148. doi: http://dx.doi.org/10.4236/oalib.1104148.
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