Introduction: Diabetes mellitus is a chronic disease
whose global expansion gives it the characteristics of a pandemic. Diabetes
risk factors are well known. In this work we proposed to study the role of
genetic polymorphism of the eNOS G894T gene in the development of diabetes on
the one hand and of these degenerative complications other. Methods: We conducted
a prospective case-control study in which we included 200 subjects divided into
100 patients with type 2 diabetes and 100 controls in apparent good health. For
each patient and control we measured lipid parameters, CRP-us and sought the
G894T polymorphism of eNOS gene by PCR-RFLP. Results: The analysis of our
results shows a statistically significant elevated TG values (p < 10﹣3), Lp (a) (p < 10﹣3),
and CRP-us (p < 10﹣3) in type 2 diabetes compared with
controls. The mutated genotypes of GT eNOS gene was significantly
more frequent in diabetic patients. In our series, we did not notice any
significant difference in genotype or allele frequency between diabetics with
and without degenerative complications. Conclusion: The G894T polymorphism of
eNOS gene appears to be a risk factor of T2DM. His role in the development of
degenerative complications remains proved.
Cite this paper
Sendesni, R. , Grira, N. , Lamine, O. , Aboulkassem, S. , Ayoub, M. , Stambouli, N. , Haroun, O. , Mazigh, C. and Aouni, Z. (2018). Endothelial Nitric Oxide Synthase (eNOS) Glu298Asp Gene Polymorphism (G894T) as a Risk Factor for Type 2 Diabetes Mellitus in the Tunisian Population. Open Access Library Journal, 5, e4171. doi: http://dx.doi.org/10.4236/oalib.1104171.
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