%0 Journal Article
%T Screening of Single Nucleotide Polymorphism in CD95 (APO-1/FAS) Promoter Region (G-1377A) in Children with Acute Leukemia
%A Dilara Fatma Akin Bali
%A Didem Torun Ozkan
%A Ahmet Emin Kurekci
%A Nejat Akar
%J Open Access Library Journal
%V 5
%N 3
%P 1-7
%@ 2333-9721
%D 2018
%I Open Access Library
%R 10.4236/oalib.1104385
%X
CD95 is a cell surface receptor involved in
apoptotic signal transmission. Deregulation of this pathway results in down
regulation of apoptosis and subsequent persistence of a malignant clone. A
single nucleotide polymorphism (SNP) resulting in guanine-to-adenine (G > A)
transition in the CD95 promoter region (position 1377) is thought to reduce
stimulatory protein 1 (SP1) transcription factor binding and decrease CD95
expression. The purpose of this study was to examine a genetic polymorphism in
the core promoter of CD95 is associated with the frequency. G-1377A in the CD95
promoter region was genotyped by polymerase chain reaction and restriction
endonuclease analysis and sequenced of the CD95 gene (Beckman Coulter, USA). Among 146 patients, CD95 G-1377A (rs2234767) SNP
carriers frequencies has been identified as 25% GA (n:37) and AA 4% (n:6),
respectively. This polymorphism of the distribution of the CD95 gene in acute
leukemic children will be a guide for future studies.
%K Acute Lymphoblastic Leukemia
%K Acute Myeloblastic Leukemia
%K CD 95 Polymorphism
%U http://www.oalib.com/paper/5293127