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Sentimento de comunidade, qualidade e satisfa？？o de vida
Elvas,Susana; Moniz,Maria Jo？o Vargas;
Análise Psicológica , 2010,
Abstract: the perceived sense of community in a specific location, as in a residential neighbourhood, provides several benefits, both individual and community level. at the individual level, the greater the sense of community, greater participation in the community, the higher capital and social support received by the neighbourly relations and greater satisfaction and quality of life. at community level, the higher for the sense of identity and belonging, the greater community empowerment, promoting healthy and sustainable communities. in our study, the participants were children and adolescents, 15 from armador neighbourhood and 15 from alfama neighbourhood, with ages ranging from 7 to 15 that were making part in local projects of communitarian intervention. with this study, we evaluate this relation and the importance of a strong sense of belonging, identity with the place, to life satisfaction and quality of life, considering it as a efficacious strategy to promote community development.
The Influence of Carbon-Carbon Multiple Bonds on the Solvolyses of Tertiary Alkyl Halides: a Grunwald-Winstein Analysis
Marina C. Reis,Ruben Elvas-Leit？o,Filomena Martins
International Journal of Molecular Sciences , 2008, DOI: 10.3390/ijms9091704
Abstract: The influence of carbon-carbon multiple bonds on the solvolyses of 3-chloro-3-methylbutyne (1), 2-chloro-2-phenylpropane (2), 2-bromo-2-methyl-1-phenylpropane (3), 4-chloro-4-methyl-2-pentyne (4) and 2-chloro-2-methylbutane (5) is critically evaluated through the extended Grunwald-Winstein equation. Substrates 1, 3 and 5 lead to correlations with unexpected negative sensitivity, h, to changes in the aromatic ring parameter, I. It is claimed that I is not a pure parameter, reflecting also some solvent nucleophilicity, NOTs, character. In substrates 2 and 4 the possibility of rearside solvation is reduced due to steric hindrance and/or cation stabilization and the best found correlations involve only the solvent ionizing power, Y, and I.
Twitter, Youtube e innovación en la promoción turística online: Análisis de las estrategias del Ministerio de Turismo de Brasil
da Cruz,Gustavo; Velozo,Thyago; Elvas Falc？o Soares,André;
Estudios y perspectivas en turismo , 2011,
Abstract: due to the enormous daily volume of promotional actions, shared and broadcasted via traditional ways, innovation on tourist promotion has become essential. having said that, virtual communities nowadays are one excellent opportunity to create and develop moments of interaction, participation and engagement as main social characters on tourism. therefore, this research aims to analyze promotional strategies performed by the ministry of tourism in brazil on twitter and youtube's virtual communities at the present year, 2010. after collected data and careful analysis, it's possible to affirm that these communities are being utilized in a significant way on tourist promotion, providing content capable of generating interaction and consequently building up a relationship with the social actors involved with tourism.
Twitter, Youtube e innovación en la promoción turística online: Análisis de las estrategias del Ministerio de Turismo de Brasil Twitter, Youtube and Innovation in Tourism Promotion Online: Brazilians Ministry of Tourism Strategies Analysis
Gustavo da Cruz,Thyago Velozo,André Elvas Falc？o Soares
Estudios y perspectivas en turismo , 2011,
Abstract: Debido al enorme volumen diario de acciones promocionales desarrolladas en los canales tradicionales, la innovación en la promoción turística se torna de fundamental importancia considerando que hoy en día las comunidades virtuales son una excelente oportunidad para crear momentos de interacción, participación y compromiso con los actores sociales del turismo. De esta forma, este estudio pretende analizar las estrategias promocionales realizadas por el Ministerio de Turismo de Brasil en las comunidades virtuales de Twitter y Youtube durante el a o 2010. Después de recolectar y analizar los datos, es posible afirmar que dichas comunidades están siendo utilizadas de forma significativa en la promoción turística, proporcionando un contenido capaz de generar interacciones y de construir relaciones entre los actores sociales involucrados en el turismo. Due to the enormous daily volume of promotional actions, shared and broadcasted via traditional ways, innovation on tourist promotion has become essential. Having said that, virtual communities nowadays are one excellent opportunity to create and develop moments of interaction, participation and engagement as main social characters on tourism. Therefore, this research aims to analyze promotional strategies performed by the Ministry of Tourism in Brazil on Twitter and YouTube's virtual communities at the present year, 2010. After collected data and careful analysis, it's possible to affirm that these communities are being utilized in a significant way on tourist promotion, providing content capable of generating interaction and consequently building up a relationship with the social actors involved with tourism.
Diabetes Alters KIF1A and KIF5B Motor Proteins in the Hippocampus
Filipa I. Baptista, Maria J. Pinto, Filipe Elvas, Ramiro D. Almeida, António F. Ambrósio
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065515
Abstract: Diabetes mellitus is the most common metabolic disorder in humans. Diabetic encephalopathy is characterized by cognitive and memory impairments, which have been associated with changes in the hippocampus, but the mechanisms underlying those impairments triggered by diabetes, are far from being elucidated. The disruption of axonal transport is associated with several neurodegenerative diseases and might also play a role in diabetes-associated disorders affecting nervous system. We investigated the effect of diabetes (2 and 8 weeks duration) on KIF1A, KIF5B and dynein motor proteins, which are important for axonal transport, in the hippocampus. The mRNA expression of motor proteins was assessed by qRT-PCR, and also their protein levels by immunohistochemistry in hippocampal slices and immunoblotting in total extracts of hippocampus from streptozotocin-induced diabetic and age-matched control animals. Diabetes increased the expression and immunoreactivity of KIF1A and KIF5B in the hippocampus, but no alterations in dynein were detected. Since hyperglycemia is considered a major player in diabetic complications, the effect of a prolonged exposure to high glucose on motor proteins, mitochondria and synaptic proteins in hippocampal neurons was also studied, giving particular attention to changes in axons. Hippocampal cell cultures were exposed to high glucose (50 mM) or mannitol (osmotic control; 25 mM plus 25 mM glucose) for 7 days. In hippocampal cultures incubated with high glucose no changes were detected in the fluorescence intensity or number of accumulations related with mitochondria in the axons of hippocampal neurons. Nevertheless, high glucose increased the number of fluorescent accumulations of KIF1A and synaptotagmin-1 and decreased KIF5B, SNAP-25 and synaptophysin immunoreactivity specifically in axons of hippocampal neurons. These changes suggest that anterograde axonal transport mediated by these kinesins may be impaired in hippocampal neurons, which may lead to changes in synaptic proteins, thus contributing to changes in hippocampal neurotransmission and to cognitive and memory impairments.
Lymph Node Metastases of Medullary Thyroid Cancer: Role of Calcitonin in the Washout Fluid of Fine-Needle Aspiration
Couto, Joana,Cunha, Nuno,Elvas, Ana Rita,Ilhéu, Olga,Marques, Bernardo,Martins, Raquel G.,Martins, Teresa,Moniz, Ana Paula,Rodrigues, Fernando,Santos, Jacinta,Valido, Frederico
- , 2020, DOI: https://doi.org/10.1155/2020/9267972
Abstract: Introduction. The diagnostic value of calcitonin (CT) measurement in fine-needle aspirate washout (FNA-CT) for medullary thyroid cancer (MTC) lymph node (LN) metastases remains to be determined. It may increase the diagnostic sensitivity, but data on this subject is sparse. Objective. Our study aimed to evaluate the utility of FNA-CT in the diagnosis of LN metastases of MTC. Methods. We retrospectively investigated, in our institutional database, 69 consecutive FNA LN cytology from 42 patients who underwent FNA cytology and CT measurement in needle washout for suspicious LN between 2012 and 2017. Results. From the total of 69 FNA, 30 (43.4%) were performed in patients with personal history of MTC. MTC was detected in 19 FNA cytology (27.5%), and CT was detectable in needle washout in 23 cases (median？=？2014 pg/mL; interquartile range？=？490–15111 pg/mL). Based on the combined results of FNA-CT and FNA cytology, LN surgical resection was performed in 33 cases (47.8%). Histology reported MTC LN metastases in 21 lesions (63.6%). Regarding the diagnosis of MTC LN metastases, FNA cytology showed sensitivity of 81.8% and specificity of 97.9%, and FNA-CT demonstrated sensitivity of 100% and specificity of 97.9%. We determined through ROC analysis an optimal FNA-CT cut-off value of 23 pg/mL for the diagnosis of LN metastases (sensitivity 100%; specificity 100%). Conclusions. FNA-CT may be a valuable diagnostic tool for detection of MTC LN metastases, along with FNA cytology, and it should be included in the clinical workup of neck adenopathies in patients with MTC or with thyroid nodules
Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage
Ana C Rodrigues-Neves,Ana R Santiago,António F Ambrósio,Christa E Müller,Eszter C Szabó,Filipe Elvas,Inês D Aires,Maria H Madeira,Pedro Tralh？o,Raquel Boia,Rodrigo A Cunha,Younis Baqi,？ngelo R Tomé
- , 2017, DOI: 10.1038/cddis.2017.451
Abstract: Transient retinal ischemia is a major complication of retinal degenerative diseases and contributes to visual impairment and blindness. Evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia reactivity may afford neuroprotection to the retina against the damage induced by ischemia–reperfusion (I–R). The available therapeutic strategies for retinal degenerative diseases have limited potential, but the blockade of adenosine A2A receptor (A2AR) emerges as candidate strategy. Therefore, we evaluated the therapeutic potential of a selective A2AR antagonist (KW6002) against the damage elicited by I–R. The administration of KW6002 after I–R injury reduced microglia reactivity and inflammatory response and afforded protection to the retina. Moreover, we tested the ability of caffeine, an adenosine receptor antagonist, in mediating protection to the retina in the I–R injury model. We demonstrated that caffeine administration dually regulated microglia reactivity and cell death in the transient retinal ischemic model, depending on the reperfusion time. At 24？h of reperfusion, caffeine increased microglial reactivity, inflammatory response and cell death elicited by I–R. However, at 7 days of reperfusion, caffeine administration decreased microglia reactivity and reduced the levels of proinflammatory cytokines and cell death. Together, these results provide a novel evidence for the use of adenosine A2AR antagonists as potential therapy for retinal ischemic diseases and demonstrate the effect of caffeine on the regulation of microglia-mediated neuroinflammation in the transient ischemic model
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