oalib

OALib Journal期刊

ISSN: 2333-9721

费用：99美元

投稿

时间不限

( 2019 )

( 2018 )

( 2012 )

( 2011 )

自定义范围…

匹配条件： “Hokazono” ，找到相关结果约12条。
列表显示的所有文章，均可免费获取
第1页/共12条
每页显示 条
Pattern-reversal electroretinograms for the diagnosis and management of disorders of the anterior visual pathway
Hokazono, Kenzo;Oyamada, Maria Kiyoko;Monteiro, Mário Luiz Ribeiro;
Arquivos Brasileiros de Oftalmologia , 2011, DOI: 10.1590/S0004-27492011000300017
Abstract: the pattern electroretinogram is an electrophysiological test that assesses the function of inner retinal layers, particularly the ganglion cells layer of retina, using a reversing checkerboard or grating pattern that produces no change in average luminance over time. the normal pattern electroretinogram is composed of a proeminent positive component (p50) and a large later negative component (n95). since structural damage that compromises the retinal ganglion cell layer can lead to pattern electroretinogram changes, particularly in the n95 amplitude, the test can be useful in the treatment of a number of anterior visual pathway diseases. in this article, we review the methods for recording pattern electroretinogram and its usefulness in the diagnosis and management of diseases including inflammatory, hereditary, ischemic and compressive lesions of the anterior visual pathway.
Tratamento da retinopatia por radia？？o com inje？？o intravítrea de bevacizumab (Avastin？): relato de caso
Lavezzo, Marcelo Mendes;Hokazono, Kenzo;Takahashi, Walter Yukihiko;
Arquivos Brasileiros de Oftalmologia , 2010, DOI: 10.1590/S0004-27492010000400016
Abstract: purpose: to report a case of radiation retinopathy treatment with intravitreal injection of bevacizumab (avastin？) in a patient undergoing radiotherapy for lymphoma in the right orbit. patient of 55 years-old male, diabetic, diagnosed with an orbital malt lymphoma three years ago, treated with local radiotherapy (dose: 35gy) two years ago, complaining of reduced visual acuity of the right eye for about four months. during the ophthalmologic evaluation, he had an exam suggestive of radiation retinopathy. macular thickness at the optical coherence tomography was 480 μm. patient was referred to intravitreal injection (0.05 ml) of bevacizumab (avastin？) in the right eye, showing reduction of macular edema and mild improvement of visual acuity. in this case, the treatment of radiation retinopathy with intravitreal injection of bevacizumab (avastin？) was relatively useful, with mild improvement of visual acuity due to the regression of macular edema.
Meningioma do nervo óptico simulando progress？o de dano axonal glaucomatoso: relato de caso
Hokazono, Kenzo;Moura, Frederico Castelo;Monteiro, Mário Luiz Ribeiro;
Arquivos Brasileiros de Oftalmologia , 2008, DOI: 10.1590/S0004-27492008000500023
Abstract: to report a case of an optic nerve sheath meningioma located at the optic canal area mimicking the progression of a glaucomatous axonal damage. a 60-year-old female patient developed progressive visual field loss and enlargement of the optic disc cup in the left eye while in treatment for primary open-angle glaucoma. because of the rapid progression of axonal loss, the asymmetry of the visual field defect and the fact that intraocular pressure had been under control, a compressive optic neuropathy was suspected. a computerized tomography scan of the orbit was normal but a high-resolution magnetic resonance imaging demonstrated an optic nerve sheath meningioma located at the optic canal area. compressive lesions of the anterior visual pathways are uncommon causes of optic disc cupping but should be considered in patients suspected of or undergoing treatment for glaucoma that present with atypical progression of visual loss.
Perfluoroctano em cavidade orbitária após vitrectomia posterior e sutura de perfurante ocular: relato de caso
Lavezzo, Marcelo Mendes;Hokazono, Kenzo;Zacharias, Leandro Cabral;Ttakahashi, Walter Yukihiko;
Arquivos Brasileiros de Oftalmologia , 2011, DOI: 10.1590/S0004-27492011000400015
Abstract: a case of a perfluoro-n-octane leakage into the orbital cavity after corneoscleral suture, scleral buckling and pars plana vitrectomy in an eye with perforating injury after trauma is reported for the first time. a previously healthy 39-year-old man was sent for ophthalmic evaluation one day after suffering a penetrating ocular trauma in his right eye while hammering a nail. on the initial evaluation, the patient presented sudden reduction of visual acuity on his right eye with a perforating corneoscleral injury, intraocular foreign body and retinal detachment. the patient was submitted to corneoscleral suture, pars plana vitrectomy with perfluoro-n-octane administration to flatten the retina and scleral buckling, when it was found transfixation of the globe by the intraocular foreign body. postoperatively, computed tomography scans of the orbit were ordered due to proptosis, which showed the presence of hyperdense images, suggesting leakage of perfluoro-n-octane into the orbital cavity. thus, in cases of perforating eye injury, one should be suspicious about the possibility of intraocular foreign body, as well as possible occurrence of transfixation of the globe when scheduling the surgery.
Síndrome do ápice orbitário causada por herpes zóster oftálmico: relato de caso e revis？o da literatura
Hokazono, Kenzo;Oliveira, Marcelo;Moura, Frederico Castelo;Monteiro, Mário Luiz Ribeiro;
Revista Brasileira de Oftalmologia , 2009, DOI: 10.1590/S0034-72802009000500009
Abstract: herpes zoster ophthalmicus (hzo) is caused by a varicella-zoster virus infection which remains latent in the ganglion of gasser until it is reactivated and compromise the ophthalmic division of the trigeminal nerve. hzo commonly causes neuro-ophthalmic complications such as vesicular lesions in the eyelids, keratoconjunctivitis, sclertis, uveitis, ocular palsy, orbital miositis and optic neuritis. hzo rarely presents as an orbital apex syndrome. this paper describes a patient with of orbital apex syndrome associate and meningitis caused by hzo which was treated with systemic steroids and acyclovir.
Púrpura trombocitopênica imunológica como manifesta？？o inicial de lúpus eritematoso sistêmico juvenil
Braga, Josefina Aparecida Pellegrini;Hokazono, Mary;Terreri, Maria Teresa R. A.;Hilário, Maria Odete E.;
Revista Brasileira de Reumatologia , 2003, DOI: 10.1590/S0482-50042003000600013
Abstract: patients with idiopathic thrombocytopenic purpura (itp) present a high trend to develop systemic lupus erythematosus (sle), especially those with chronic presentation. some authors observed that female gender, older patients and familial history of autoimmune disease in patients with idiopathic thrombocytopenic purpura are factors that lead to increased susceptibility for the development of systemic lupus erythematosus. based on these facts, we decided to study 5 children with chronic idiopathic thrombocytopenic purpura and late systemic lupus erythematosus. in this paper, we describe the clinical and laboratorial features of 5 female children with idiopathic thrombocytopenic purpura that later developed systemic lupus erythematosus. all patients were girls, 3 caucasian, with idiopathic thrombocytopenic purpura onset age ranged between 6 years and 3 months and 12 years and 1 month (mean - 9 years and 2 months). the age at systemic lupus erythematosus diagnosis ranged between 8 years and 13 years and 8 months (mean - 10 years and 10 months). though, the gap between idiopathic thrombocytopenic purpura and systemic lupus erythematosus diagnosis ranged between 11 months and 2 years and 9 months (mean - 1 year and 10 months). all patients presented chronic idiopathic thrombocytopenic purpura (thrombocytopenia lasts longer than 6 months). the systemic lupus erythematosus classification criteria were (in decreasing frequency): malar erythema and positivity of ana in 5 patients; arthritis, hematological (thrombocytopenia) and immunological alterations (positivity of anti-dna) in 4 patients; photosensitivity and positivity of anti-cardiolipin in 3 patients. other manifestations included oral ulcers, renal involvement, leukopenia and auto-immune hemolytic anemia, serositis (pericarditis), neurological involvement and positivity of anti-sm antibody. we would like to emphasize this form of presentation of systemic lupus erythematosus, in which the idiopathic thrombocytopenic pu
Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study
Hokazono, Mary;Silva, Gisele Sampaio;Silva, Edina Mariko Koga;Braga, Josefina Aparecida Pellegrini;
Sao Paulo Medical Journal , 2011, DOI: 10.1590/S1516-31802011000300003
Abstract: context and objective: transcranial doppler (tcd) detects stroke risk among children with sickle cell anemia (sca). our aim was to evaluate tcd findings in patients with different sickle cell disease (scd) genotypes and correlate the time-averaged maximum mean (tamm) velocity with hematological characteristics. design and setting: cross-sectional analytical study in the pediatric hematology sector, universidade federal de s？o paulo. methods: 85 scd patients of both sexes, aged 2-18 years, were evaluated, divided into: group i (62 patients with sca/s？0 thalassemia); and group ii (23 patients with sc hemoglobinopathy/s？+ thalassemia). tcd was performed and reviewed by a single investigator using doppler ultrasonography with a 2 mhz transducer, in accordance with the stroke prevention trial in sickle cell anemia (stop) protocol. the hematological parameters evaluated were: hematocrit, hemoglobin, reticulocytes, leukocytes, platelets and fetal hemoglobin. univariate analysis was performed and pearson's coefficient was calculated for hematological parameters and tamm velocities (p < 0.05). results: tamm velocities were 137 ± 28 and 103 ± 19 cm/s in groups i and ii, respectively, and correlated negatively with hematocrit and hemoglobin in group i. there was one abnormal result (1.6%) and five conditional results (8.1%) in group i. all results were normal in group ii. middle cerebral arteries were the only vessels affected. conclusion: there was a low prevalence of abnormal doppler results in patients with sickle-cell disease. time-average maximum mean velocity was significantly different between the genotypes and correlated with hematological characteristics.
Disseminated zoster in an adult patient with extensive burns: a case report
Kentaro Kosaka,Motone Kuriyama,Nobuyuki Mitsukawa,Shinsuke Akita,Takafumi Tezuka,Toshinori Hokazono,Yoshihisa Yamaji,Yoshitaka Kubota
- , 2019, DOI: 10.1186/s12985-019-1179-8
Abstract:
Development of a simple indocyanine green measurement method using an automated biochemical analyser
Eisaku Hokazono,Kazuyuki Matsushita,Masanori Seimiya,Susumu Osawa,Toshihiko Yoshida,Yuji Sawabe,Yuka Sato
- , 2018, DOI: 10.1177/0004563217745895
Abstract: The indocyanine green retention rate is important for assessing the severity of liver disorders. In the conventional method, blood needs to be collected twice. In the present study, we developed an automated indocyanine green method that does not require blood sampling before intravenous indocyanine green injections and is applicable to an automated biochemical analyser. The serum samples of 471 patients collected before and after intravenous indocyanine green injections and submitted to the clinical laboratory of our hospital were used as samples. The standard procedure established by the Japan Society of Hepatology was used as the standard method. In the automated indocyanine green method, serum collected after an intravenous indocyanine green injection was mixed with the saline reagent containing a surfactant, and the indocyanine green concentration was measured at a dominant wavelength of 805？nm and a complementary wavelength of 884？nm. The coefficient of variations of the within- and between-run reproducibilities of this method were 2% or lower, and dilution linearity passing the origin was noted up to 10？mg/L indocyanine green. The reagent was stable for four weeks or longer. Haemoglobin, bilirubin and chyle had no impact on the results obtained. The correlation coefficient between the standard method (x) and this method (y) was r=0.995; however, slight divergence was noted in turbid samples. Divergence in turbid samples may have corresponded to false negativity with the standard procedure. Our method may be highly practical because blood sampling before indocyanine green loading is unnecessary and measurements are simple
A novel assay for triglycerides using glycerol dehydrogenase and a water
Eisaku Hokazono,Hirotaka Matsui,Masahiro Manabe,Miki Kawano,Shouichi Sato,Susumu Osawa,Takiko Tateishi,Yuzo Kayamori
- , 2019, DOI: 10.1177/0004563219830715
Abstract: The glycerol-3-phosphate (GPO)-peroxidase (POD) chromogenic method is one of the most widely used methods to assay triglycerides. However, it is well known that peroxidase is affected by reducing agents, and recently, it has been reported that some materials affect its activity. Moreover, there is a high possibility of non-specific reaction, as the method uses many enzymes. Against this background, we developed a simpler assay method for triglycerides without using peroxidase. Triglycerides were hydrolysed to glycerol and fatty acids by lipoprotein lipase followed by the oxidation of glycerol to dihydroxyacetone with simultaneous production of NADH by glycerol dehydrogenase. To overcome incomplete conversion of glycerol to dihydroxyacetone by glycerol dehydrogenase at equilibrium, we added 2-(2-methoxy-4-nitrophenyl)-3–(4-nitrophenyl)-5–(2,4-disulfophenyl)-2H-tetrazolium monosodium salt (WST-8) to the reaction mixture to remove NADH, allowing the reaction to complete while showing stoichiometric production of reduced WST-8. The reaction was linear up to 6.4？mmol/L. The mean intra-assay (n？=？20) and inter-assay (n？=？20) imprecision, as determined by replicate analysis of three pooled human serum samples with different triglyceride concentrations, were 1.1–2.3% and 1.1–1.5% coefficient of variation (%CV), respectively. No interference by 2.5 g/L haemoglobin, 65？μmol/L free bilirubin and 359？μmol/L conjugated bilirubin was observed. The equation obtained in comparison with that by the GPO-POD method including endogenous glycerol-eliminating step was: y？=？1.0002x？+？0.0395？mmol/L; r？=？0.999; Sy/x？=？0.049？mmol/L; n？=？97. Our method is an accurate, yet simpler and more sensitive for the quantitative analysis of triglycerides
第1页/共12条
每页显示 条


Home
Copyright © 2008-2020 Open Access Library. All rights reserved.