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台湾新竹科学工业园区的特色及启示
,曾晓萱
科技导报 , 1998,
Abstract: 70年代,台湾经济面临严峻挑战。世界新技术革命的飞速发展,自动化、计算机技术的大量使用,越来越多地挤压着台湾的劳动密集型产品市场。随着台湾岛内的经济的发展,劳动力成本逐年升高,台湾产品的价格竞争力下降。加之国际贸易保护主义抬头,欧美采取种种措施增加进口障碍,致使台湾无法再依靠劳动密集型工业维持其经济发展。70年代的能源危机,又使台湾重化工业受到严重打击。种种压力下,迫使台湾当局只能调整产业结构,促进产业升级,发展技术密集的高技术产业。新竹科学工业园区由此产生。
二月桂酸二丁基锡对大鼠肝脏毒性作用
学军,朱健,,刘乾,邓立权,倪亚杰,刘基芳
中国公共卫生 , 2006, DOI: 10.11847/zgggws2006-22-04-45
Abstract: ?目的用二月桂酸二丁基锡(DBTD)染毒大鼠,探讨DBTD对大鼠肝脏及血清中酶活性的影响。方法选健康成年大鼠28只,随机分为0,5,10,20mg/kg4个剂量组,每组7只动物,用DBTD灌胃染毒5周后处死动物,测定血清中碱性磷酸酶(ALP)、谷丙转氨酶(GPT)、γ-谷氨酰基转移酶(GGT)、肝组织中酸性磷酸酶(ACP)、碱性磷酸酶(AKP)、乳酸脱氢酶(LDH)活性及肝脏中锡含量。结果各剂量组大鼠肝脏中锡含量,肝组织中ACP、AKP、LDH,血清中ALP、GGT、GPT活性明显高于对照组(P<0.01,P<0.05)。结论DBTD可在肝组织中蓄积,具有肝毒性,可影响肝中酶的活性及肝的正常功能。
被动吸烟对仔鼠学习记忆功能影响及干预效应
姜丽,学军,李君文,刘基芳
中国公共卫生 , 2006, DOI: 10.11847/zgggws2006-22-03-28
Abstract: ?目的研究小鼠孕期被动吸烟对其子代学习、记忆功能的影响,并探讨不同抗氧化剂对吸烟危害的改善作用。方法建立被动吸烟模型,设立对照组、吸烟组和抗氧化剂干预组;吸烟染毒3个月后产子代,利用小鼠在方型水迷宫中学习、记忆能力的变化,通过组间对照评价吸烟组和抗氧化剂干预组的不同影响结果,及干预在子代中的改善作用。结果各干预组子代的游泳成绩均随学习时间的增加而提高,吸烟组子代提高的速度最慢;水迷宫测试第1,4,8和12d,吸烟组小鼠子代的潜伏期明显高于对照组子代;测试12d时,维生素E(VE)干预组潜伏期与吸烟组比较明显降低;由达标后的结果分析可见,被动吸烟组子代小鼠的错误次数与对照组比较有增高趋势。结论胚胎期被动吸烟使小鼠学习记忆功能下降,通过抗氧化剂的干预可能得到改善。
液化场地桩-土相互作用大变形无网格法分析
邱天爽,,里红杰
大连理工大学学报 , 2010, DOI: 10.7511/dllgxb201004020
Abstract: 非高斯非平稳随机信号处理是当前信号处理领域的研究热点,具有重要的理论意义和实际价值.采用TVAR模型来描述非平稳随机信号,在α稳定分布噪声条件下,传统的递推最小二乘(RLS)算法效果显著退化.采用最小\%p\%范数(LPN)算法对TVAR模型的时变参数进行估计,仿真实验结果表明,LPN算法不仅适用于高斯条件而且适用于非高斯α稳定分布噪声条件,且与仅适用于高斯条件下的RLS算法相比具有更好的韧性.
吡格列酮或胰岛素治疗对2型糖尿病患者血尿酸的影响
刘媛媛,谢晓,
天津医药 , 2012,
Abstract: ?目的:比较吡格列酮或胰岛素治疗对2型糖尿病患者(type2diabetesmellitust2dm)血糖及血尿酸的影响。方法:133名2型糖尿病合并高尿酸血症的患者随机分为3组,监测12周治疗前后空腹血糖、餐后2h血糖、糖化血红蛋白、血尿酸、肌酐、总胆固醇和甘油三酯。结果:吡格列酮组治疗后空腹血糖、餐后2h血糖、糖化血红蛋白、血尿酸、甘油三酯、总胆固醇等均较治疗前下降(p<0.05)。胰岛素治疗组空腹血糖、餐后2h血糖、hba1c均较治疗前显著下降(p<0.05)。胰岛素组治疗前后空腹血糖、餐后2h血糖和hba1c均低于吡咯列酮和常规治疗组(p<0.05)。吡格列酮组降低尿酸的作用显著高于胰岛素治疗组。常规治疗组降低血尿酸作用高于吡咯列酮组和胰岛素组。结论:胰岛素组的降糖作用最强。吡格列酮显著降低血尿酸。对于2型糖尿病合并高尿酸血症,无痛风的患者,宜选用吡格列酮。
可降解咖啡碱菌株的筛选与鉴定
吴薇,李博,,籍保平,null
- , 2010,
Abstract: 目的:筛选能够降解咖啡碱的细菌,以期在该毒素的生物脱毒中得到应用。方法:以咖啡碱作为唯一碳源和氮源进行咖啡碱降解菌株的初筛,之后将初筛的10 株菌通过液体培养基咖啡碱降解实验最终筛选出降解能力最强的1 株菌。结果:筛选出的HZ-1 菌株在48h 即可将咖啡碱完全降解,对目标菌株细胞形态、生理生化以及16SrDNA 进行鉴定,确定该菌株为Pseudomonas lutea,属于假单胞菌属。结论:利用咖啡碱作为唯一碳源和氮源从土壤中筛选出降解咖啡碱良好的菌株,为脱除咖啡碱提供了微生物菌种,填补了国内空白
应用于干摩擦振动系统中的Galerkin法
Galerkin Method Applied to the Vibration System with Dry Friction
 [PDF]


Open Journal of Acoustics and Vibration (OJAV) , 2019, DOI: 10.12677/OJAV.2019.74017
Abstract:
本文主要研究一个受干摩擦作用的振动系统的周期解的近似求解。此系统的周期解近似地表示Fourier级数,并通过Galerkin法把微分方程转换成非线性代数方程组,利用Broyden法来对此非线性代数方程组求解。最后数值积分的结果用来验证该方法的有效性。
In this paper, the approximate periodic solution of a vibration system subjected to dry friction is studied. The periodic solution of this system approximately represents the Fourier series, the dif-ferential equation is transformed into nonlinear algebraic equations by Galerkin method, and the nonlinear algebraic equations are solved by Broyden method. Finally, numerical integration results are used to verify the effectiveness of the method.
PHYTOLITH ANALYSIS: MORPHOLOGICAL CHARACTERISTICS OF PEATLAND PLANT SPECIES IN CHANGBAI MOUNTAINS
长白山泥炭湿地主要植物植硅体形态特征研究

介冬梅,刘红梅,葛勇,郭梅娥,
第四纪研究 , 2011,
Abstract: Phytolith analysis is an important method in the reconstruction of paleoenvironment.It is also an useful tool in the fields of paleoecology,environmental archaeology,and plant taxonomy.The research on applying phytolith analysis in peatland to reconstruct paleobotany and paleoenvirnment depends on the study on modern plant phytoliths.In this paper,phytoliths from 25 genera,31 species from peatlands aroud Changbai Mountains were analyzed.The paper focused on the morphological differences of phytoliths,the phytolith morpho-types could be classified into 15 categories,they were silicified stomata,elongate,fan-shaped,plate-shaped,silicious tuber,point-shaped,tooth-shaped,and hat-shaped,and a small amount of vessel,dumbell,multilateral-hat-shaped,saddle-shaped,crosstie-shaped,trichoid-shaped.Peatland plant species from Gramineae,Equisetaceae,Violaceae,and Rubiaceae were found of large amount of phytoliths.A special type of point-shaped phytolith was found in Solidago virgaurea,a new type of phytolith was found in the Beckmannia syzigachne and named as crossite-shaped,this could be a useful supplementary to Gramineae phytoliths classifications.The cluster analysis for width of silicified stomata found that the width of silicified stomata is an humidity indicator,the wider the silicified stomata,the wetter the environment.More quantitive researches on the size of silicified stomata could be helpful for the reconstruction of paleoenvironment and concentrations of carbon dioxide,and the study of morphological characteristics of peatland plant phytoliths could help the reconstruction of the paleoenvironment of peatland.PCA(Principal Component Analysis)for main phytolith types of plants in the peatland found that the combination of elongate,dumbbell,silicious tuber and point-shaped represented wet and cold climate.There was little differences found among the phytoliths assemblages from five peatlands,it was considered as the elevation differences counteracted the latitude differences.
一种模糊人工免疫网络故障诊断策略
庄健,,杜海峰,苟世宁,茂林,王孙安
自然科学进展 , 2007,
Abstract: 基于免疫系统与故障诊断系统在作用机制上的相似性,在建立通用的人工免疫网络故障诊断模型的基础上,提出一种基于模糊人工免疫网络的故障诊断算法.文中的免疫系统故障诊断模型,把故障诊断问题建模为抗体-抗原识别和作用问题;设计克隆选择,免疫记忆等故障诊断的免疫规则;并基于故障诊断问题的先验知识,提出一种模糊人工免疫网络故障诊断算法.UCI(University of California,Irvine)标准数据集和一个四级压缩机故障诊断试验表明,该算法能充分利用故障数据的先验信息,快速准确地获得数据样本特征,实现数据的聚类,从而完成故障诊断.
Development and Application of Screening Method for Steroid Dihydrofolate Reductase Inhibitors by High Performance Capillary Electrophoresis
二氢叶酸还原酶抑制剂的高效毛细管电泳法筛选模型的建立与应用

JIA Rui,LI Na,ZHU Ruohua,
贾蕊
,,朱若华

色谱 , 2007,
Abstract: A novel screening method for dihydrofolate reductase inhibitors (DHFRI) using high performance capillary electrophoresis (HPCE) was developed. The separation was performed in a fused silica capillary column using disodium tetraborate (50 mmol/L, pH 9. 18) buffer solution with 0. 002% Brij-35. The separation temperature was controlled at 25 degrees C and a voltage of 25 kV was applied. The detection wavelength was 280 nm. Five microL of various concentrations of inhibitor was added to the enzyme reaction system consisting of 25 micrpL of 50 mmol/L pH 6. 0 potassium phosphate buffer, 10 microL of 0. 025 mg/mL dihydrofolate (FH2), 10 microL of dihydrofolate reductase (DHFR) (0. 25 unit) and 5 microL of 0. 5 mg/mL NADPH in a 300-miL sample tube, then mixed for 1 min and incubated for 30 min at room temperature. The reaction mixture injections were performed by pressure at 3.45 kPa (0. 5 psi) for 10 s. With the developed CE method the substrate and product were baseline resolved within 19 min. The time course of the reaction was studied to show excellent correlation. Quantitative analysis of DHFR inhibition was performed by determining its dynamic parameters. The difference of peak areas between FH2 and FH4 was used to calculate the inhibitory rate. Three inhibitors, amethopterin, trimethoprim and folic acid, were used in the enzyme reaction system to test this method and their IC50 values determined were close to the literature values. It was demonstrated that the developed method is suitable for screening DHFRIs.
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