Background: Vitamin B12 (Cobalamin) one of the most
important vitamins for its normal functioning to maintain the nerve system and for
their role in production of DNA. Objective: This study was aimed to measure and
assess the serum Cobalamin levels in Sudanese patients with Sickle-cell disease
(SCD) and compared with those without Sickle-cell disease. Materials and Method:
This is a case control study conducted in Sudan during March 2015. A total of
160 volunteers were enrolled in this study. 80 were known Sudanese patients professionally diagnosed with homozygous
sickle cell; their age ranged from 6 months to 15 years as patients group. Further 80 normal healthy were as control group; their age and gender were similar to patient group.
Serum was prepared from clotted blood samples. The Cobalamin concentrations
were measured in both groups of SCD patients and in a normal healthy control
group using Enzyme Linked Immune immunosorbent assay method (ELISA), Map lap
Plus-Italy. For statistical analysis, the laboratory parameters were compared
between the two groups and tested for statistical significance using
Statistical package for social scent (SPSS) version 20. Result: In this study
the mean of serum Cobalamin in the sickle cell patients was statistically
significantly lower compared with the normal non-sickle cell disease group with p value = 0.01. Conclusion: 7.1% of Sudanese sickle cell disease has a deficient
serum Cobalamin (hypocobalaminemia).
Cite this paper
Ahmed, I. I. , Sir-Elfatouh, A. M. and Gaufri, N. E. A. M. (2016). Significant Reduction of Vitamin B12 Levels in Sudanese Sickle Cell Disease Patients. Open Access Library Journal, 3, e3208. doi: http://dx.doi.org/10.4236/oalib.1103208.
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