Background: The prevalence of Human Immunodeficiency
Virus (HIV) infection was 1.2% in the Democratic Republic of Congo, according
to the Demographic Health Study report in 2014. In 2012, the severe failure
rate to first-line ART in Kinshasa was estimated at more than 16%. Objective: The objective of this study is to
determine the rate of clinical, immunological and virological failure in
first-line treatment in Kinshasa. Methodology: At the 6th month of Antiretroviral Treatment (ART), 138
patients from a follow-up cohort of 8 centers in Kinshasa were received for
paraclinical evaluations and analyses. The clinical and paraclinical parameters were recorded on the individual
patient sheets as well as the survey forms. Clinical parameters, viral load and
CD4 were evaluated at the 6th month of ART. Results: One hundred and thirty-eight (138) patients had returned for
follow-up treatment, 81 women and 57 men. The average age of patients is 37 ±
12 years. The dominant age groups are those of 26 to 35 years and 36 to 45
years with 39 patients (28.3%) each, followed by those of 18 to 25 years
(21.7%). One hundred and twenty-five (125) patients (90.5%) were in clinical
stage 3 and 13 (9.5%) in clinical stage 4 according to the WHO classification.
CD4 levels ranged from 98 to 1050 cells/mm3 and a median value of
560 cells/mm3. The median value of the patients’ VLs was 0.90 log10 copies of RNA/ml with respective minimum and maximum values of 0 and 4.82 log10 copies of RNA/ml. The virological failure rate was 24.6%. Conclusions: The rate of virological
failure of first-line antiretroviral treatment of patients under treatment in
Kinshasa is 24.6% for the year 2015.
Cite this paper
Kamangu, E. N. (2018). Estimation of Clinical, Immunological and Virological Failure of First Line Antiretroviral Treatment in Kinshasa, Democratic Republic of Congo. Open Access Library Journal, 5, e4560. doi: http://dx.doi.org/10.4236/oalib.1104560.
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