A 49 year old gentleman presented with intermittent bilateral knee swelling
for the past 37 years and was eventually diagnosed as primary hypertrophic
osteoarthropathy after secondary forms were excluded. This case illustrates
that the disease can present during childhood with an insidious onset and
progressively become more severe and that is when medical attention is
sought. Furthermore, the patient did not voluntarily report his skin changes
as he considered the slow progressive changes as normal. We report a case of
primary hypertrophic osteoarthropathy, its clinical presentation, imaging
findings and therapeutic treatment. It is a rare differential diagnosis for
chronic joint pain and swelling.
Cite this paper
Ng, C. and Loh, Y. (2019). A Clinical Triad of Digital Clubbing, “Arthritis” and Ossifying Periostitis in a Man: Case Report. Open Access Library Journal, 6, e5101. doi: http://dx.doi.org/10.4236/oalib.1105101.
Gómez Rodríguez, N., Ibánez Ruán, J. and González Pérez, M. (2009) Primary Hypertrophic Osteoarthropathy (Pachydermoperiostosis). Report of 2 Familial Cases and Literature Review. Reumatología Clínica, 5, 259-263.
https://doi.org/10.1016/j.reuma.2009.01.007
Touraine, A., Solente, G. and Gole, L. (1935) Un syndrome osteodermopathique: La pachydermie plicaturee avec pachyperiostose des extremites. La Presse Médicale, 43, 1820-1824.
Karnan, S., Krishnamoorthy, V., Ethiraj, P. and Sathynathan, B.P. (2012) Touraine-Solente-Gole Syndrome. The Complete form Needs to Be Recognised. Indian Journal of Nuclear Medicine, 27, 201-204.
Offret, H., Venencie, P.Y., Fain, J., Quillard, J. and Badarani, N. (1996) Involvement of the Connective Tissue of the Eyelids in Pachydermoperiostosis. Journal Francais D’Ophtalmologie, 19, 64-68. [Article in French].
Kabashima, K., Sakabe, J., Yoshiki, R., Tabata, Y., Kohno, K. and Tokura, Y. (2010) Involvement of Wnt Signaling in Dermal Fibroblasts. The American Journal of Pathology, 176, 721-732. https://doi.org/10.2353/ajpath.2010.090454
Martinez-Lavin, M., Vargas, A. and Rivera-Vinas, M. (2008) Hypertrophic Osteoarthropathy: A Palindrome with a Pathogenic Connotation. Current Opinion in Rheumatology, 20, 88-91. https://doi.org/10.1097/BOR.0b013e3282f14a5a