Neuroendocrine tumors are a rare and aggressive histological variant of the cervix, and they have several differences compared to other types of cervical cancer, in prognosis, diagnosis and treatment. In this paper we report the case of a 39-year-old patient that was taken care of in the medical oncology department at the Hassan II University Hospital Center, for an advanced neuroendocrine carcinoma of the cervix with a Sister Mary Joseph’s nodule. The aim of this work is to highlight this rare location of neuroendocrine tumors and their very aggressive character; by describing the different clinical, radiological and anatomopathological aspects of the primary tumor as well as umbilical metastasis.
Cite this paper
Darif, K. , Oualla, K. , Hazzaz, R. E. , Zouiten, O. , Siyouri, O. , Acharfi, N. , Boujarnija, R. , Amaadour, L. , Benbrahim, Z. , Arifi, S. and Mellas, N. (2020). Neuroendocrine Carcinoma of the Cervix with Sister Mary Joseph's Nodule: About a Case and Literature Review. Open Access Library Journal, 7, e6874. doi: http://dx.doi.org/10.4236/oalib.1106874.
Albores-Saavedra, J., Larraza, O., Poucell, S. and Rodríguez Martínez, H.A. (1976) Carcinoid of the Uterine Cervix: Additional Observations on a New Tumor Entity. Cancer, 38, 2328-2342.
https://doi.org/10.1002/1097-0142(197612)38:6<2328::AID-CNCR2820380620>3.0.CO;2-J
Tempfer, C.B., Tischoff, I., Dogan, A., Hilal, Z., Schultheis, B., Kern, P. and Rezniczek, G.A. (2018) Neuroendocrine Carcinoma of the Cervix: A Systematic Review of the Literature. BMC Cancer, 18, 530.
Kim, J.Y., Hong, S.M. and Ro, J.Y. (2017) Recent Updates on Grading and Classification of Neuroendocrine Tumors. Annals of Diagnostic Pathology, 29, 11-16.
https://doi.org/10.1016/j.anndiagpath.2017.04.005
Gadducci, A., Carinelli, S. and Aletti, G. (2017) Neuroendrocrine Tumors of the Uterine Cervix: A Therapeutic Challenge for Gynecologic Oncologists. Gynecologic Oncology, 144, 637-646. https://doi.org/10.1016/j.ygyno.2016.12.003
Castle, P.E., et al. (2018) A Systematic Review and Meta-Analysis on the Attribution of Human Papillomavirus (HPV) in Neuroendocrine Cancer of the Cervix. Gynecologic Oncology, 148, 422-429. https://doi.org/10.1016/j.ygyno.2017.12.001
Gardner, G.J., Reidy-Lagunes, D. and Gehrig, P.A. (2011) Neuroendocrine Tumors of the Gynecologic Tract: A Society of Gynecologic Oncology (SGO) Clinical Document. Gynecologic Oncology, 122, 190-198.
https://doi.org/10.1016/j.ygyno.2011.04.011
Satoh, T., Takei, Y., Treilleux, I., Devouassoux-Shisheboran, M., Ledermann, J., Viswanathan, A.N., Mahner, S., Provencher, D.M., Mileshkin, L., Åvall-Lundqvist, E., Pautier, P., Reed, N.S. and Fujiwara, K. (2014) Gynecologic Cancer InterGroup (GCIG) Consensus Review for Small Cell Carcinoma of the Cervix. International Journal of Gynecological Cancer, 24, S102-S108.
https://doi.org/10.1097/IGC.0000000000000262
Yin, Z.M., Yu, A.J., Wu, M.J., Fang, J., Liu, L.F., Zhu, J.Q. and Yu, H. (2015) Effects and Toxicity of Neoadjuvant Chemotherapy Preoperative Followed by Adjuvant Chemoradiation in Small Cell Neurdendocrine Cervical Carcinoma. European Journal of Gynaecological Oncology, 36, 326-329.
Nasu, K., Hirakawa, T., Okamoto, M., Nishida, M., Kiyoshima, C., Matsumoto, H., Takai, N. and Narahara, H. (2011) Advanced Small Cell Carcinoma of the Uterine Cervix Treated by Neoadjuvant Chemotherapy with Irinotecan and Cisplatin Followed by Radical Surgery. Rare Tumors, 3, e6. https://doi.org/10.4081/rt.2011.e6
Hoskins, P.J., Swenerton, K.D., Pike, J.A., Lim, P., Aquino-Parsons, C., Wong, F. and Lee, N. (2003) Small-Cell Carcinoma of the Cervix: Fourteen Years of Experience at a Single Institution Using a Combined-Modality Regimen of Involved-Field Irradiation and Platinum-Based Combination Chemotherapy. Journal of Clinical Oncology, 21, 3495-3501. https://doi.org/10.1200/JCO.2003.01.501
Bermúdez, A., Vighi, S., García, A. and Sardi, J. (2001) Neuroendocrine Cervical Carcinoma: A Diagnostic and Therapeutic Challenge. Gynecologic Oncology, 82, 32-39. https://doi.org/10.1006/gyno.2001.6201
Tso, S., Brockley, J., Recica, H. and Ilchyshy, A. (2013) Sister Mary Joseph’s Nodule: An Unusual But Important Physical Finding Characteristic of Widespread Internal Malignancy. British Journal of General Practice, 63, 551-552.
https://doi.org/10.3399/bjgp13X673900
Gabriele, R., Conte, M., Egidi, F. and Borghese, M. (2005) Umbilical Metastasis: Current Viewpoint. World Journal of Surgical Oncology, 3, Article No. 13.
Schoijet, I.M., Rojas, A.A., Cortés, C. and Varela, C.U. (2018) Sister Mary Joseph’s Nodule: From the History to the Images. A Case-Based Literature Review. Acta Gastroenterologica Latinoamericana, 48, 82-89.