%0 Journal Article
%T O papel do gene e da mol¨¦cula HLA-G na express£¿o cl¨ªnica das doen£¿as reumatol¨®gicas
%A Brenol
%A Claiton Viegas
%A Veit
%A Tiago Degani
%A Chies
%A Jos¨¦ Artur Bogo
%A Xavier
%A Ricardo Machado
%J Revista Brasileira de Reumatologia
%D 2012
%I Sociedade Brasileira de Reumatologia
%R 10.1590/S0482-50042012000100009
%X human leukocyte antigen g (hla-g) is a non-classic class i major histocompatibility complex (mhc) molecule characterized by low polymorphism in its coding region, a limited tissue distribution pattern in physiologic conditions, and expression through soluble isoforms and isoforms bound to surface membranes through alternative splicing. hla-g is fairly known since it is involved in induction and maintenance of tolerance between the maternal immunologic system and the semi-allogeneic fetus at the level of the fetal-placental interface. besides, several studies have indicated a wider immunoregulatory role of this molecule. in this context, the expression of hla-g in inflammatory and rheumatologic diseases is a relatively recent research area. the first studies described the expression of hla-g in several inflammatory myopathies, atopic dermatitis, and cutaneous psoriasis. based on the findings that hla-g could divert t helper responses to the th2 type, it was hypothesized that hla-g would be a protective molecule in inflammatory responses. in this article, we review the potential roles of the hla-g molecule in the immune system and in several rheumatologic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and others
%K hla antigens
%K rheumatologic diseases
%K genetic polymorphism.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0482-50042012000100009&lng=en&nrm=iso&tlng=en