%0 Journal Article
%T Leucopenia e trombocitopenia induzidas por etanercepte: relato de dois casos e revis£¿o da literatura
%A Azevedo
%A Valder¨ªlio Feij¨®
%A Silva
%A Mar¨ªlia Barreto Gameiro
%A Marinello
%A D¨¦bora Karine
%A Santos
%A Felipe Dunin dos
%A Silva
%A Guilherme Barreto Gameiro
%J Revista Brasileira de Reumatologia
%D 2012
%I Sociedade Brasileira de Reumatologia
%R 10.1590/S0482-50042012000100011
%X tumor necrosis factor-alpha (tnf-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. those effects are known to be antagonized by tnf-alpha inhibitors. etanercept is a fusion protein that inhibits tnf-alpha action. as tnf-alpha regulation is related to cellular differentiation of various cellular types involved in immune response through expression of several other cytokines, it is possible that the use of its inhibitors may cause cytopenia. we report two cases of bicytopenia induced by etanercept. both cases recovered after drug withdrawal. we discuss the need of introduction of routine laboratorial tests in patients using anti-tnf therapy, in order to identify possible hematological changes
%K biological products
%K neutropenia
%K leukopenia
%K thrombocytopenia
%K biological therapy.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0482-50042012000100011&lng=en&nrm=iso&tlng=en