%0 Journal Article
%T Efecto de la suplementaci¨®n con Vimang£¿ sobre indicadores de estr¨¦s oxidativo en j¨®venes con diabetes mellitus tipo 1
%A Escobar Aedo
%A Adri¨¢n Luis
%A P¨¦rez Ortega
%A Yipsi
%A Vera Gonz¨¢lez
%A Manuel
%A Pe£¿aranda Guzm¨¢n
%A Odensys
%A ¨¢lvarez Le¨®n
%A Alina
%J Revista Cubana de Endocrinolog£¿-a
%D 2011
%I Scientific Electronic Library Online
%X introduction: the oxidative stress plays a fundamental role in the pathogenesis of diabetes mellitus complications. vimang£¿ (a natural antioxidant product) has been successfully used diseases characterized by an increase of oxidative stress. objective: to assess the effect of vimang£¿ on the redox state in young people presenting with type 1 diabetes mellitus. methods: a phase ii clinical, randomized, controlled unicenter trial to assess the antioxidant effectiveness tablets vimang£¿ in young people with type 1 diabetes mellitus including 50 patients located into two groups (25 each) who received 300 mg tablets vimang£¿ every eight hours and placebo, respectively was carried out. the glycemia control was assessed by glycosylated hemoglobin, a complete lipidic profile and hemochemical determinations were carried out. the variables of damage due to oxidative stress were assessed: peroxidation potential, total hydroperoxides, advanced products of the protein oxidation, malonylaldehyde and the reduced glutathione endogenous antioxidant. determinations were made before and at 3 months of intervention. groups were compared each other, in the two times as well as in an internally regarding the basal state previous to supplementation with vimang£¿ or placebo. results: the peroxidation potential increased at three months in both groups (p < 0,05), only decreased in the 25 % of the patients under supplementation. there was an increase of malonylaldehyde (p < 0,05), of total hydroperoxides (p < 0,01) and a also a decrease of reduced glutathione (p = 0,01) at three months in patients under treatment. it was neither related to supplementation nor to metabolic control, which improved in both groups. conclusions: vimang£¿ was not an effective antioxidant in the dose used in type 1 diabetes mellitus patients.
%K type 1 diabetes mellitus
%K vimang£¿
%K oxidative stress
%K antioxidants.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1561-29532011000200005&lng=en&nrm=iso&tlng=en