%0 Journal Article
%T Growth Hormone Deficiency (GHD) in Adults: To Treat or Not To Treat?
%A Boguszewski
%A Cesar Luiz
%J Revista argentina de endocrinolog£¿-a y metabolismo
%D 2010
%I Scientific Electronic Library Online
%X over the last decade, different guidelines have been published for the diagnosis, treatment and monitoring of adult growth hormone deficiency (aghd). themes and recommendations common to the guidelines offer a pragmatic approach to the management of aghd. nevertheless, there is a need for more research in some key areas in which recommendations in the guidelines are supported by moderate evidence, at best. recent meta-analysis and long-term follow-up studies have contributed with valuable information on the efficacy and safety of gh therapy in adults. this review brings a historical perspective of the aghd, with an emphasis on the following aspects: (i) who are the appropriate candidates for gh therapy in adult life? (ii) how to make the diagnosis (iii) the impact of gh therapy; (iv) which therapeutic approach should be used? (v) how to follow and monitor the patients; and (vi) special aspects on mortality and longevity related to the gh-igf-1 axis.
%K growth hormone
%K deficiency
%K hypopituitarism
%K young adult
%K hormone replacement therapy.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S1851-30342010000300005&lng=en&nrm=iso&tlng=en