%0 Journal Article
%T Efecto de variantes de los genes ABCB1 y CYP3A4 sobre la respuesta terap¨¦utica a atorvastatina en individuos chilenos hipercolesterol¨¦micos
%A Rosales Z
%A Alexy
%A Salazar
%A Luis A
%J Revista chilena de cardiolog¨ªa
%D 2011
%I Scientific Electronic Library Online
%R 10.4067/S0718-85602011000200004
%X background: : statins are effective in the control of hypercholesterolemia. however, the therapeutic response to these drugs presents a great inter-individual variability. factors such as age, gender and ethnicity have been associated to this variability. recent studies show that polymorphisms can influence the lipid-lowe-ring response to statins. the aim of the present study was to investigate the effect of three polymorphisms 3435c>t (abcb1), 2677g>a/t (abcb1) and -290 a>g (cyp3a4) gene on the response to atorvastatin treatment in chilean hypercholesterolemic individuals. methods: 94 hypercholesterolemic individuals, were treated with atorvastatin, 10mg/day for 4 weeks. we determined serum levels of total cholesterol, hdl-c, ldl-c and triglycerides, before and after treatment. the polymorphisms were analyzed by pcr-rflp. results: significant reductions were observed in total cholesterol (275 ¡À 18 vs. 235 ¡À 22 mg/dl, p<0.001), ldl-c (183 ¡À 16 vs. 146 ¡À 24 mg/dl, p<0.001) and triglycerides levels (225 ¡À 48 vs. 172 ¡À 51 mg/dl, polymorphisms on the therapeutic hypercholesterolemic individuals p<0.001). in addition, an increase in the hdl-c levels was observed (47 ¡À 10 vs. 55 ¡À 7, p<0.001). the genotype distribution for 3535c>t variant of abcb1 gene was: cc=47.9%, ct=41.5% and tt=10.6%. the genotype distribution for 2677g>a/t polymorphism (abcb1) was aa=1.1%, ga=14.9%, gt=28.7%, ta=9.6%, tt=8.5% and gg=37.2%. the genotype distribution for -290a>g variant of cyp3a4 gene was: aa=77.7%. ag=22.3% and gg=0.0 %. subjects carrying the g allele for the -290 a>g variant of the cyp3a4 gene, exhibited a greater reduction in total cholesterol (p=0.001) and ldl-c levels (p<0.001). no differences were observed for the other polymorphisms studied. conclusion: this study suggests that the therapeutic response to atorvastatin (10mg/day during 4 weeks) is influenced by the -290 a>g variant of cyp3a4 gene.
%K polymorphisms
%K cyp3a4
%K atorvastatin
%K abcb1.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0718-85602011000200004&lng=en&nrm=iso&tlng=en