%0 Journal Article
%T Rash y anemia apl¨¢sica inducidos por fenito¨ªna: caso cl¨ªnico
%A Soto V
%A ¨¢lvaro
%A Lavados M
%A Manuel
%A Araya D
%A Fernando
%J Revista chilena de neuro-psiquiatr¨ªa
%D 2011
%I Scientific Electronic Library Online
%R 10.4067/S0717-92272011000200007
%X rash is a common side effect associated with antiepileptic drugs. the rate of a phenytoin rash is 5.9% and increases to 25% in those with another antiepileptic drug rash. aplastic anemia is an adquired hematopoietic stem-cell disorder characterized by pancytopenia of the peripheral blood and hypocellular bone marrow. the use of phenytoin is associated with a 3.5 fold increased risk of aplastic anemia. we report a case of a 70-year-old woman who developed two severe adverse reactions simultaneously with phenytoin: a maculopapular pruritic rash with involvement of mucous and an aplastic anemia. both conditions normalized after phenytoin withdrawal.
%K phenytoin
%K rash
%K aplastic anemia
%K antiepileptic drugs
%K adverse drug reactions.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-92272011000200007&lng=en&nrm=iso&tlng=en