%0 Journal Article
%T E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
%A Mart¨ªnez
%A A
%A Spencer
%A ML
%A Borlando
%A J
%A Flores
%A M
%A Rojas
%A IG
%J Revista cl¨ªnica de periodoncia, implantolog¨ªa y rehabilitaci¨®n oral
%D 2011
%I Scientific Electronic Library Online
%R 10.4067/S0719-01072011000300008
%X objective: the aim of this study was to assess epithelial expression of e-cadherin and c-met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. study design: biopsies of normal lip vermillion (nl, n=18), actinic cheilitis (ac, n=37), and lip scc (n=22) were processed for e-cadherin and c-met immunodetection. epithelial and tumor cell expression was scored for each sample considering staining intensity and percentage. results: e-cadherin expression was significantly reduced in ac and lip scc as compared to normal lip (p<0.05), with a significant reduction in lip scc as compared to ac (p=0.003). expression of c-met was significantly higher in ac and lip scc as compared to nl (p<0.05), with a significant increase in lip scc as compared to ac (p<0.0001). conclusion: the results showed that epithelial e-cadherin expression is reduced and c-met expression is increased as lip carcinogenesis progresses, suggesting that these proteins may be useful markers of malignant transformation.
%K e-cadherin
%K c-met
%K lip carcinogenesis
%K uv light
%K actinic cheilitis
%K lip squamous cell carcinoma.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0719-01072011000300008&lng=en&nrm=iso&tlng=en