%0 Journal Article
%T Asociaci¨®n entre niveles de TNF-¦Á en fluido crevicular gingival de dientes con periodontitis apical asintom¨¢tica
%A Garrido Flores
%A M
%A Ordenes Vitali
%A T
%A Seg¨² Cabrera
%A C
%A Baeza Paredes
%A M
%A Garc¨ªa-Sesnich
%A J
%A Hern¨¢ndez R¨ªos
%A M
%J Revista cl¨ªnica de periodoncia, implantolog¨ªa y rehabilitaci¨®n oral
%D 2011
%I Scientific Electronic Library Online
%R 10.4067/S0719-01072011000300010
%X introduction: as a consequence of septic pulp necrosis, the entry of bacterial products into periapical tissues induces the release of pro-inflammatory cytokines, such as the tumor necrosis factor (tnf)- a. this pleiotropic cytokine is involved in the differentiation and activation of osteoclasts to induce bone resorption, a hallmark of asymptomatic apical periodontitis (aap). gingival crevicular fluid (gcf) has a great potential as a source of factors associated with osteoclastic activity. the aim of this study was to determine the levels of tnf- a in gcf of teeth with paa and contralateral healthy controls. methods: a total of 14 patients with clinical diagnosis of aap were enrolled from the clinic of endodontics, faculty of dentistry, universidad de chile during 2009 and 30-second gcf samples were obtained with paper strips from aap teeth and contralateral healthy controls. total protein concentration and tnf- a levels were determined through bisciconitic acid method and elisa assay, respectively. paired t test and statav11 software were used for statistical analysis. results: levels of tnf- a were significantly higher in gcf from teeth with aap than controls when standardized by either 30s of sampling and total protein content. conclusions: the present study provides preliminary data supporting that tnf- a levels in gcf reflect periapical status. screening of tnf- a levels in gcf might represent a useful side-diagnostic tool to the monitoring of the apical status.
%K tnf- a
%K asimptomatic apical periodontitis
%K gingival crevicular fluid.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0719-01072011000300010&lng=en&nrm=iso&tlng=en