%0 Journal Article
%T Presencia de marcadores de las v¨ªas de activaci¨®n de los macr¨®fagos en periodontitis cr¨®nica
%A Navarrete
%A M
%A Garc¨ªa-Sesnich
%A J
%A Dutzan
%A N
%A Henr¨ªquez
%A L
%A Puente
%A J
%A Gamonal
%A J
%J Revista cl¨ªnica de periodoncia, implantolog¨ªa y rehabilitaci¨®n oral
%D 2012
%I Scientific Electronic Library Online
%R 10.4067/S0719-01072012000300006
%X periodontitis is a chronic infectious disease caused by a bacterial species complex, which affects mainly the insertion tissues of the teeth. the immune-inflammatory response produced is characterized by an inflammatory infiltrate in which macrophages represent between 5 to 30%. it is known and has been widely discussed that macrophages are activated in two ways: classical and alterna, characterized by the presence of indirect markers: ifn-¦Ã and il-6 for the classical pathway and il-4 for the alternative pathway. recently the subunit a of the clotting factor xiii (fxiii-a) has been described as a good marker of the alternative pathway. the objective of this study is to determine the presence of ifn-¦Ã, il-6, il-4 and fxiii-a as markers of the macrophage activation pathways in patients with chronic periodontitis. to this end, we performed immunohistochemistry and western blot for the four markers with cd68 macrophage marker, in 18 healthy periodontal tissue biopsies and 18 with chronic periodontitis. we detected the presence of ifn-¦Ã, il-6, il-4 and fxiii-a with cd68 +, in all samples of healthy patients and periodontitis. the results suggest that when present, ifn-¦Ã, il-6, il-4 and fxiii-a, activate macrophages through both routes, which would produce a proinflammatory response (th1) as antiinflammatory (th2). further studies are necessary to determine whether there is a preferential pathway activation.
%K factor xiii-a
%K macrophages
%K periodontitis.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0719-01072012000300006&lng=en&nrm=iso&tlng=en