%0 Journal Article
%T CAPACIDAD PROTECTORA CONFERIDA A LAS CR¨ªAS POR ANTICUERPOS MATERNOS INDUCIDOS POR UN CANDIDATO VACUNAL DE SUBUNIDAD PROTEICA (E2)
%A Vega
%A E
%A Barrera
%A Maritza
%A Abeledo
%A Mar¨ªa A
%A del Pilar Rodr¨ªguez
%A M
%A Teresa Fr¨ªas
%A M
%A Figueredo
%A JM
%A Chong
%A Daine
%A Bulnes
%A C
%A Castell
%A Sara
%J Revista de Salud Animal
%D 2011
%I Centro Nacional de Sanidad Agropecuaria
%X four groups of pigs of 34 days old were conformed in order to evaluate the protective capacity conferred for maternal antibodies to offspring from mothers vaccinated with a vaccine candidate of protein subunit e2, against classical swine fever virus (csfv), obtained for adenoviral vector transduced to the mammary gland of goats, against challenge with a highly pathogenic strain (margarita) at doses of 104 pid50 (infective doses 50% pigs). groups 1 and 2 were conformed by five pigs with passively transferred maternal antibodies from mothers vaccinated with a vaccine candidate of protein subunit e2, and groups 3 and 4 (control groups ), conformed by three seronegative pigs to classical swine fever (csf), determined by neutralizing peroxidase linked assay (npla). the groups 1 and 3 were challenged by intranasal route and groups 2 and 4 by intramuscular route. the pigs with passively transferred maternal antibodies from mothers vaccinated and challenge by intranasal and intramuscular route were negative to viraemia and mortality; while those from the control groups were found sick and not protected for viraemia after challenge. the control group challenge for intramuscular route presented a smaller time of onset of the infectious process with respect to the group challenged by intranasal route.
%K classical swine fever
%K maternal antibodies
%K margarita strain
%K vaccine candidate of protein subunit (e2).
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0253-570X2011000300005&lng=en&nrm=iso&tlng=en