%0 Journal Article
%T Molecular characterization of alpha-thalassemia in the Mexican population
%A Reyes-Nu£¿¨¦z
%A Virginia
%A Garc¨¦s-Eisele
%A Javier
%A Jorge
%A Susan
%A Kimura
%A Elza
%A Ferreira-Costa
%A Fernando
%A Sonati
%A Mar¨ªa de F¨¢tima
%A Ruiz-Reyes
%A Guillermo
%J Revista de investigaci¨®n cl¨ªnica
%D 2006
%I Scientific Electronic Library Online
%X background. ¦Á-thalassemia (¦Á-thal) has been poorly characterized at the molecular level in mexico. methods. 106 consecutive individuals identified in laboratorios cl¨ªnicos de puebla, with either hypochromia (mch < 24 pg) and/or microcytosis (mcv < 75 fl in women or < 80 fl in man), without iron deficiency, with or without anemia were investigated in this study, along a 16 month-period, ¦Á and ¦Â-thal were looked for, the former were characterized at the molecular level. results. out of the 106 consecutive cases with hypochromia and/or microcytosis and normal levels of protoporphyrin zinc complex, 48 cases (45.3%) had thalassemia (37 cases of ¦Â-thal and 11 cases of ¦Á-thal), whereas in 58 cases (54.7%) a definite diagnosis could not be established. of the ¦Á-thal cases, 8 were heterozygous and two were homozygous for the -¦Á3.7 deletion, whereas one case was heterozygous for the ¦Á2hph allele. conclusions. only few of the ¦Á-thal alleles tested were found, thus the ¦Á-thalassemic mutations, present in the studied population, seem to be rather heterogeneous.
%K thalassemia
%K anemia
%K mexico.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S0034-83762006000300007&lng=en&nrm=iso&tlng=en