%0 Journal Article
%T Niveles s¨¦ricos de metaloproteinasa 9 (mmp-9) y del inhibidor tisular de mmp tipo 1 (timp-1) en pacientes venezolanos con asma o con enfermedad pulmonar obstructiva cr¨®nica (epoc)
%A Larocca
%A Nancy Elizabeth
%A Moreno
%A Dolores
%A Garmendia
%A Jenny
%A De Sanctis
%A Juan Bautista
%J Revista de la Facultad de Medicina
%D 2010
%I Scientific Electronic Library Online
%X serum levels of metalloproteinase (mmp) 9, an enzyme involved in inflammation, and its counterpart, the tissue inhibitor of metalloproteinases type 1 (timp-1) are significantly (p < 0.01) increased in patients with asthma or with chronic obstructive pulmonary disease (copd) as compared with controls of the same age. the increase in both parameters is more significant (p < 0.0001) in severe patients of both groups, and particularly in patients with severe copd as compared to severe asthmatics (p < 0.01). the increase in serum mmp-9 levels in relation with severity is higher than the observed values for timp-1 in both diseases. it is concluded that serum levels of mmp-9 and timp-1 may be important markers to establish severity in these diseases.
%K asthma
%K copd
%K metalloproteinase
%K mmp-9
%K inhibitor of metalloproteinase 1 (timp-1).
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0798-04692010000100002&lng=en&nrm=iso&tlng=en