%0 Journal Article
%T Mutaciones asociadas con resistencia a rifampicina o isoniazida en aislamientos cl¨ªnicos de M. tuberculosis de Sonora, M¨¦xico
%A Bolado-Mart¨ªnez
%A Enrique
%A P¨¦rez-Mendoza
%A Ansix
%A Alegr¨ªa-Morquecho
%A Francisco Monserrat
%A Candia-Plata
%A Mar¨ªa del Carmen
%A Aguayo-Verdugo
%A Mar¨ªa del Rosario
%A ¨¢lvarez-Hern¨¢ndez
%A Gerardo
%J Salud P¨²blica de M¨¦xico
%D 2012
%I Instituto Nacional de Salud P¨²blica
%R 10.1590/S0036-36342012000200013
%X objective: to perform the analysis of specific regions of the major genes associated with resistance to isoniazid or rifampin. materials and methods: twenty two m. tuberculosis strains, isolated from human samples obtained in sonora, mexico. specific primers for hotspots of the rpob, katg, inha genes and the ahpc-oxyr intergenic region were used. the purified pcr products were sequenced. results: mutations in the promoter of inha, the ahpc-oxyr region, and codon 315 of katg and in 451 or 456 codons of rpob, were identified. conclusions: detection of mutations not previously reported requires further genotypic analysis of mycobacterium tuberculosis isolates in sonora.
%K mycobacterium
%K mutation
%K drug resistance
%K isoniazid
%K rifampin.
%U http://www.scielosp.org/scielo.php?script=sci_abstract&pid=S0036-36342012000200013&lng=en&nrm=iso&tlng=en