%0 Journal Article
%T Cyclooxygenase-2 and human epidermal growth factor receptor type 2 (HER-2) expression simultaneously in invasive and in situ breast ductal carcinoma
%A Lucarelli
%A Adrienne Pratti
%A Martins
%A Maria Marta
%A Montor
%A Wagner
%A Oliveira
%A Vilmar
%A Galv£¿o
%A Maria Antonieta Longo
%A Piato
%A Sebasti£¿o
%J Sao Paulo Medical Journal
%D 2011
%I Scientific Electronic Library Online
%R 10.1590/S1516-31802011000600002
%X context and objective: cyclooxygenase-2 (cox-2) and human epidermal growth factor receptor type 2 (her-2) are associated with tumorigenesis. studies have shown that her-2 can regulate cox-2 expression. the aim of this study was to evaluate the correlation between cox-2 and her-2 expression in normal breast epithelium and in ductal carcinoma in situ (dcis) and invasive ductal carcinoma (idc) present in the same breast. design and setting: cross-sectional study at the mastology unit of the department of gynecology and obstetrics, santa casa de miseric¨®rdia de s£¿o paulo hospital. methods: cox-2 and her-2 were detected using immunohistochemistry on 100 tissue fragments. her-2 > +2 was subjected to fluorescence in situ hybridization (fish). results: cox-2 expression was detected in 87%, 85% and 75% of idc, dcis and normal epithelium, respectively. her-2 expression was detected in 34% of idc and 34% of dcis. cox-2 in dcis correlated with her-2 in idc (p = 0.049) and dcis (p = 0.049). cox-2 in normal epithelium correlated with her-2 in idc (p = 0.046) and dcis (p = 0.046). cox-2 in idc was not associated with her-2 (p = 0.235). comparison between cox-2 and her-2 in dcis showed that there was a statistically significant difference with regard to nuclear grades ii and iii and presence of comedonecrosis (p < 0.001). in idc, there was significant expression with nuclear grades ii and iii and histological grade ii (p < 0.001). conclusions: our findings provide evidence that her-2 and cox-2 regulate each other
%K cyclooxygenase 2
%K receptor
%K erbb-2
%K breast neoplasms
%K carcinoma
%K intraductal
%K noninfiltrating
%K carcinoma
%K ductal
%K breast.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-31802011000600002&lng=en&nrm=iso&tlng=en