%0 Journal Article
%T Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review
%A Alvarenga
%A C¨¦sar Augusto
%A Lopes
%A Jos¨¦ Manuel
%A Vinagre
%A Jo£¿o
%A Paravidino
%A Paula Itagyba
%A Alvarenga
%A Marcelo
%A Prando
%A Adilson
%A Castilho
%A L¨ªsias Nogueira
%A Soares
%A Paula
%A Billis
%A Athanase
%J Sao Paulo Medical Journal
%D 2012
%I Scientific Electronic Library Online
%R 10.1590/S1516-31802012000100010
%X context: extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. case report: this report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. the patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. it was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral s100 protein expression in sustentacular cells. succinate dehydrogenase a and b-related (sdha and sdhb) expression was present in both tumors. conclusions: no genetic alterations to the vhl and sdhb genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
%K paraganglioma
%K carcinoma
%K renal cell
%K seminal vesicles
%K kidney neoplasms
%K mutation.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-31802012000100010&lng=en&nrm=iso&tlng=en