%0 Journal Article
%T Enzyme inhibition of dopamine metabolism alters 6-[18 F]FDOPA uptake in orthotopic pancreatic adenocarcinoma
%A Johanna Tuomela
%A Sarita Forsback
%A Laura Haavisto
%A Tero Vahlberg
%A Tove J Gr nroos
%A Olof Solin and Merja Haaparanta-Solin
%J EJNMMI Research
%D 2013
%I Springer
%R 10.1186/2191-219X-3-18
%X Combined use of [18F]FDG and [18F]FDOPA is suitable for imaging pancreatic tumours. Unequal pancreatic uptake after the employed enzyme inhibitors is due to the blockade of metabolism and therefore increased availability of [18F]FDOPA metabolites, in which uptake differs from that of [18F]FDOPA. Pretreatment with COMT + MAO-A inhibitors improved the differentiation of pancreas from the surrounding tissue and healthy pancreas from tumour. Similar advantage was not achieved using carbidopa.
%U http://www.ejnmmires.com/content/3/1/18/abstract