%0 Journal Article
%T Proposal for environmental mixture risk assessment in the context of the biocidal product authorization in the EU
%A Thomas Backhaus
%A Rolf Altenburger
%A Michael Faust
%A Daniel Frein
%A Tobias Frische
%A Per Johansson
%A Anja Kehrer and Tobias Porsbring
%J Environmental Sciences Europe
%D 2013
%I BioMed Central
%R 10.1186/2190-4715-25-4
%X A tiered approach was developed that accommodates different data situations, optimizes resource usage, limits biotesting as far as possible and ensures adequate protection of the environment. It mainly builds on using Concentration Addition as a component-based approach for mixture toxicity prediction, complemented by whole product tests where appropriate. Concentration Addition is either approximated by summing up PEC/PNEC ratios or as sums of toxic units. The competing concept of Independent Action was assessed as not being suitable for incorporation into a tiered approach without explicit confirmatory studies, as it might otherwise lead to an underestimation of the actual environmental risk.
%U http://www.enveurope.com/content/25/1/4/abstract