%0 Journal Article
%T Non-Intercalative Triterpenoid Inhibitors of Topoisomerase II: A Molecular Docking Study
%A William N. Setzer
%J The Open Bioactive Compounds Journal
%D 2009
%I 
%R 10.2174/1874847300801010013]
%X Theoretical flexible docking studies were carried out on a number of triterpenoids previously shown to be inhibitors of topoisomerase II in order to assess the nature of binding of these non-intercalative inhibitors to the enzyme. The molecular docking results suggest that most of the triterpenoids preferentially bind to the DNA binding site of topoisomerase II, while a few also bind to the ATP binding site. These results provide some insight into the mode of activity of these cytotoxic natural products.
%U http://www.benthamscience.com/open/tobcj/articles/V001/13TOBCJ.htm