%0 Journal Article
%T N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats
%A Julija Matijevi -Sosa
%A Ita Samar ija
%A Lorena Honovi
%A Bla enka Juri i
%J Acta Pharmaceutica
%@ 1846-9558
%D 2008
%I 
%R 10.2478/v10007-008-0010-7
%X The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg-1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg-1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.
%K N-phthaloyl-glycine-hydroxamic acid
%K iron chelators
%K iron overload
%U http://versita.metapress.com/content/p14h1352630247x6/?p=adce938b7e324fb6ba126dfecaad07a7&pi=9