%0 Journal Article
%T Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives
%A Hanaa M. Hosni
%A Mohamed M. Abdulla
%J Acta Pharmaceutica
%@ 1846-9558
%D 2008
%I 
%R 10.2478/v10007-008-0005-4
%X In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5H-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6- (2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.
%K pyridinedicarbonitrile
%K benzopyranopyridine
%K anti-inflammatory
%K analgesic agents
%U http://versita.metapress.com/content/e62548p61745t2p7/?p=adce938b7e324fb6ba126dfecaad07a7&pi=3