%0 Journal Article
%T Osteoporoza Uzrokovana Glukokortikoidima
%A Bo idar  urkovi
%J Archives of Industrial Hygiene and Toxicology
%D 2007
%I 
%R 10.2478/v10004-007-0004-8
%X Glucocorticoids are the most common cause of drug-induced osteoporosis. Given the widespread use of oral glucocorticoids in the treatment of autoimmune, pulmonary, gastrointestinal disorders and organ transplantation, attention to glucocorticoid-induced osteoporosis has substantially increased. Bone loss occurs rapidly in the first few months of glucocorticoid therapy. Trabecular bone is affected more than cortical bone. Glucocorticoid treatment is associated with a substantially increased risk of fractures, particularly hip and vertebral fractures. The skeletal effects of glucocorticoids are both dose- and duration-dependent. The patophysiology of glucocorticoid-induced osteoporosis is a complex process, several mechanisms are proposed but not yet fully highlighted. Despite several evidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis and the availability of effective therapeutic options, the proportion of individuals with appropriate evaluation and treatment remains relatively low.
%K drug-induced osteoporosis
%K osteoclastogenesis
%K osteoporosis management
%K pathophysiology
%K risk of fractures
%U http://versita.metapress.com/content/411qr54v6t473164/?p=aef765eaab0e4d07a0292ef33132a066&pi=2