%0 Journal Article
%T Effect of Calitropis Procera Aqueous Root Extract Against CCL4 Induced Liver Toxicity in Rabbits
%A AJ Alhassan
%A MS Sule
%A MK Atiku
%A AM Wudil
%A MA Dangambo
%A JA Mashi
%A M Zaitun
%A GK Uba
%J Bayero Journal of Pure and Applied Sciences
%D 2012
%I Bayero University
%X The hepatocurative effect of aqueous root extract of Calitropis Procera on CCl4 induced hepatotoxicity in rabbits was studied in groups of rabbit and the levels of liver enzymes; aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP). Serum concentrations of total bilirubin and direct bilirubin were found to be significantly (p<0.05) higher in group induced with hepatotoxicity, with significantly (p<0.05) lower total protein and urea compared to the control group. These findings confirmed induction of hepatotoxicity. Three different dosages were orally administred (1.0g/kg, 2.5g/kg and 3.6 g/kg) twice daily for 9 days. The C. Procera root extract was found to significantly (p<0.05) reduce the serum levels of AST, ALT, and ALP, serum concentration of total bilirubin in rats with hepatotoxicity compared to the the control group and significantly (p<0.05) incerased the serum concentration of total protein and urea. These indicates the possible hepatocurative effects of aqueous root extract of C. Procera on CCl4 induced liver toxicity.
%U http://www.ajol.info/index.php/bajopas/article/view/80935