%0 Journal Article
%T Metabolic syndrome among Ghanaian patients presenting with chronic kidney disease
%A WKBA Owiredu
%A RKD Ephraim
%A BA Eghan Jnr
%A N Amidu
%A EF Laing
%J Journal of Medical and Biomedical Sciences
%D 2012
%I University for Development Studies
%X Metabolic syndrome (MetS) is a general risk factor for cardiovascular and chronic kidney disease (CKD) in Western populations. This study assessed the relationship between MetS and its compo-nents in Ghanaian patients presenting with CKD. The study population comprised of 146 non-dialysed individuals with CKD with mean age of 50.2¡À1.1 years. Eighty (80) age and sex matched healthy participants without kidney pathology were used as controls. Estimated GFR (eGFR) was calculated using the 4-variable Modification of Diet in Renal Disease (4v-MDRD) and CKD was defined as eGFR<60 ml/min/1.73m2. MetS was defined as the presence of three or more of the following risk factors according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria: elevated blood pressure (BP), low high density lipoprotein cho-lesterol (HDL-C), high triglycerides (TG), elevated plasma glucose and abdominal obesity. The prevalence of MetS in this study was 30.1% and a significant relationship was observed between the number of MetS components and the presence CKD. The CKD group are about 3 times at risk of developing MetS as compared to the control group (95% CI=0.9-8.8). Female participants with CKD are 9 fold at risk of developing MetS as compared to the male counterparts (95% CI=1.7-47.9). The CKD patients were about 2 fold at risk of developing hypertension (95% CI=1.7-3.3) and dia-betes (95% CI=1.2-2.6), about 3 times at risk of developing hypertriglyceridaemia (95% CI=1.1-5.5) and approximately 4 times at risk of developing proteinuria (95% CI=2.7-7.0). Increased WC, TG and SBP are components of the metabolic syndrome which contribute to the initiation and pro-gression of CKD.
%U http://www.ajol.info/index.php/jmbs/article/view/80225