%0 Journal Article
%T Chemo-Enzymatic Synthesis of Glycolyl-Ester-Linked Taxol-Monosaccharide Conjugate and Its Drug Delivery System Using Hepatitis B Virus Envelope L Bio-Nanocapsules
%A Kei Shimoda
%A Manabu Hamada
%A Masaharu Seno
%A Tadakatsu Mandai and Hiroki Hamada
%J Biochemistry Insights
%D 2012
%I 
%R 10.4137/BCI.S9824
%X Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2"-O-¦Á-D-glucoside, was achieved by using ¦Á-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2"-O-¦Á-D-glucoside (21 ¦ÌM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2"-O-¦Á-D-glucoside to human hepatocellular carcinoma NuE cells.
%U http://www.la-press.com/chemo-enzymatic-synthesis-of-glycolyl-ester-linked-taxol-monosaccharid-article-a3259