%0 Journal Article
%T Management Options in Triple-Negative Breast Cancer
%A Christina A. Minami
%A Debra U. Chung and Helena R. Chang
%J Breast Cancer: Basic and Clinical Research
%D 2012
%I 
%R 10.4137/BCBCR.S6562
%X Notorious for its poor prognosis and aggressive nature, triple-negative breast cancer (TNBC) is a heterogeneous disease entity. The nature of its biological specificity, which is similar to basal-like cancers, tumors arising in BRCA1 mutation carriers, and claudin-low cancers, is currently being explored in hopes of finding the targets for novel biologics and chemotherapeutic agents. In this review, we aim to give a broad overview of the disease¡¯s nomenclature and epidemiology, as well as the basic mechanisms of emerging targeted therapies and their performance in clinical trials to date.
%U http://www.la-press.com/management-options-in-triple-negative-breast-cancer-article-a2781