%0 Journal Article
%T Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence
%A Stephan Gebel
%A Rosemarie B. Lichtner
%A Brian Frushour
%A Walter K. Schlage
%A Vy Hoang
%A Marja Talikka
%A Arnd Hengstermann
%A Carole Mathis
%A Emilija Veljkovic
%A Michael Peck
%A Manuel C. Peitsch
%A Renee Deehan
%A Julia Hoeng and Jurjen W. Westra
%J Bioinformatics and Biology Insights
%D 2012
%I 
%R 10.4137/BBI.S11154
%X Towards the development of a systems biology-based risk assessment approach for environmental toxicants, including tobacco products in a systems toxicology setting such as the ¡°21st Century Toxicology¡±, we are building a series of computable biological network models specific to non-diseased pulmonary and cardiovascular cells/tissues which capture the molecular events that can be activated following exposure to environmental toxicants. Here we extend on previous work and report on the construction and evaluation of a mechanistic network model focused on DNA damage response and the four main cellular fates induced by stress: autophagy, apoptosis, necroptosis, and senescence. In total, the network consists of 34 sub-models containing 1052 unique nodes and 1538 unique edges which are supported by 1231 PubMed-referenced literature citations. Causal node-edge relationships are described using the Biological Expression Language (BEL), which allows for the semantic representation of life science relationships in a computable format. The Network is provided in .XGMML format and can be viewed using freely available network visualization software, such as Cytoscape.
%U http://www.la-press.com/construction-of-a-computable-network-model-for-dna-damage-autophagy-ce-article-a3578