%0 Journal Article
%T Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia
%A Emanuel Schwarz
%A Rauf Izmailov
%A Michael Spain
%A Anthony Barnes
%A James P. Mapes
%A Paul C. Guest
%A Hassan Rahmoune
%A Sandra Pietsch
%A F. Markus Leweke
%A Matthias Rothermundt
%A Johann Steiner
%A Dagmar Koethe
%A Laura Kranaster
%A Patricia Ohrmann
%A Thomas Suslow
%A Yishai Levin
%A Bernhard Bogerts
%A Nico (JM) van Beveren
%A George McAllister
%A Natalya Weber
%A David Niebuhr
%A David Cowan
%A Robert H. Yolken and Sabine Bahn
%J Biomarker Insights
%D 2012
%I 
%R 10.4137/BMI.S4877
%X We describe the validation of a serum-based test developed by Rules-Based Medicine which can be used to help confirm the diagnosis of schizophrenia. In preliminary studies using multiplex immunoassay profiling technology, we identified a disease signature comprised of 51 analytes which could distinguish schizophrenia (n = 250) from control (n = 230) subjects. In the next stage, these analytes were developed as a refined 51-plex immunoassay panel for validation using a large independent cohort of schizophrenia (n = 577) and control (n = 229) subjects. The resulting test yielded an overall sensitivity of 83% and specificity of 83% with a receiver operating characteristic area under the curve (ROC-AUC) of 89%. These 51 immunoassays and the associated decision rule delivered a sensitive and specific prediction for the presence of schizophrenia in patients compared to matched healthy controls.
%U http://www.la-press.com/validation-of-a-blood-based-laboratory-test-to-aid-in-the-confirmation-article-a2049