%0 Journal Article
%T Virilizing Leydig-Sertoli Cell Ovarian Tumor Associated with Endometrioid Carcinoma of the Endometrium in a Postmenopausal Patient: Case Report and General Considerations
%A Paola Di Giacinto
%A Laura Chioma
%A Giuseppe Vancieri
%A Laura Guccione
%A Elena Cicerone
%A Salvatore Ulisse
%A Stefania Mariani
%A Camillo Autore
%A Andrea Fabbri
%A Lucio Gnessi and Costanzo Moretti
%J Clinical Medicine Insights: Case Reports
%D 2012
%I 
%R 10.4137/CCRep.S10555
%X Introduction: Sertoli-Leydig cell tumors (SLCTs) are rare tumors mostly occurring in young women. Here we report an unusual case of a SLCT with simultaneous occurrence of endometrioid adenocarcinoma of the endometrium in a woman in menopause. Case report: A 67-year-old woman presented with progressive signs of virilization. Blood tests showed increased levels of testosterone, delta-4-androstenedione, and dehydroepiandrosterone (DHEA). DHEA-sulphate, 17 -estradiol, estrone, and sex-hormone binding globulin serum levels were within the normal range. Magnetic resonance imaging revealed a solid mass of 2.7 กม 2.9 cm in the right ovary set against the background of the uterus. The patient underwent bilateral salpingo-oophoretomy with hysterectomy. The mass in the right ovary was a differentiated SLCT. Incidentally, the endometrium revealed an endometrioid adenocacinoma. Following surgical treatment the plasma androgens dropped to normal levels, and signs and symptoms of virilization improved. Conclusion: SLCT should be suspected in postmenopausal women who present rapid progressive androgen excess symptoms with hyperandrogenemia.
%U http://www.la-press.com/virilizing-leydig-sertoli-cell-ovarian-tumor-associated-with-endometri-article-a3398