%0 Journal Article
%T Capsaicin - the Hot and Spicy Diet Turned Mild and Effective by Glycosylation
%A Henrik Toft Simonsen
%J Biochemistry Insights
%D 2012
%I 
%X Shimoda and co-workers published a paper on the pharmacological properties of glycosides of the peppery compound capsaicin (1 ) and its derivative 8-nordihydrocapsaicin (2). In their paper they conclude that the ¦Ā-glucoside and ¦Ā-maltoside of 1 and the ¦Ā-glucoside of 2 still have the same potent anti-obese activity but further studies are needed to determine the physiological effect. Shimoda et al.1 use glycosylation to make a drug candidate more water soluble to promote their research for new drug candidates within the chemical group of capsaicinoids. Their findings support that this is a plausible way to enhance both bioavailability and ”°drug-likeliness”± properties of drug candidates. This is indeed an interesting approach which should be pursued further and by many more.
%U http://www.la-press.com/capsaicin---the-hot-and-spicy-diet-turned-mild-and-effective-by-glycos-article-a1531