%0 Journal Article
%T Musculo-Skeletal Abnormalities in Patients with Marfan Syndrome
%A Ali Al Kaissi
%A Elisabeth Zwettler
%A Rudolf Ganger
%A Simone Schreiner
%A Klaus Klaushofer and Franz Grill
%J Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
%D 2012
%I 
%R 10.4137/CMAMD.S10279
%X Background: A leptosomic body type is tall and thin with long hands. Marfanoid features may be familial in nature or pathological, as occurs in congenital contractual arachnodactyly (Beal¡¯s syndrome) and Shprintzen-Goldberg syndrome mimicking some of the changes of Marfan syndrome, although not accompanied by luxation of lens and dissecting aneurysm of aorta. Methods: In this article we collected eight patients who were consistent with the diagnosis of Marfan syndrome via phenotypic and genotypic characterization. Results: Our patients manifested a constellation of variable presentations of musculo-skeletal abnormalities ranging from developmental dysplasia of the hip, protrusio acetabuli, leg length inequality, patellar instability, scoliosis, to early onset osteoarthritis. Each abnormality has been treated accordingly. Conclusion: This is the first paper which includes the diagnosis and the management of the associated musculo-skeletal abnormalities in patients with Marfan syndrome, stressing that patients with Marfan syndrome are exhibiting great variability in the natural history and the severity of musculo-skeletal abnormalities.
%U http://www.la-press.com/musculo-skeletal-abnormalities-in-patients-with-marfan-syndrome-article-a3498