%0 Journal Article
%T Urinary Excretion of Phenolic Acids by Infants and Children: A Randomised Double-Blind Clinical Assay
%A J. Uberos
%A V. Fern¨¢ndez-Puentes
%A M. Molina-Oya
%A R. Rodr¨ªguez-Belmonte
%A A. Ru¨ªz-L¨®pez
%A P. Tortosa-Pinto
%A A. Molina-Carballo and A. Mu oz-Hoyos
%J Clinical Medicine Insights: Pediatrics
%D 2012
%I 
%R 10.4137/CMPed.S9349
%X Objectives: The present study, which is part of the ISRCTN16968287 clinical assay, is aimed at determining the effects of cranberry syrup or trimethoprim treatment for UTI. Methods: This Phase III randomised clinical trial was conducted at the San Cecilio Clinical Hospital (Granada, Spain) with a study population of 192 patients, aged between 1 month and 13 years. Criteria for inclusion were a background of recurrent UTI, associated or otherwise with vesico-ureteral reflux of any degree, or renal pelvic dilatation associated with urinary infection. Each child was randomly given 0.2 mL/Kg/day of either cranberry syrup or trimethoprim (8 mg/mL). The primary and secondary objectives, respectively, were to determine the risk of UTI and the levels of phenolic acids in urine associated with each intervention. Results: With respect to UTI, the cranberry treatment was non-inferior to trimethoprim. Increased urinary excretion of ferulic acid was associated with a greater risk of UTI developing in infants aged under 1 year (RR 1.06; CI 95% 1.024¨C1.1; P = 0.001). Conclusions: The results obtained show the excretion of ferulic acid is higher in infants aged under 1 year, giving rise to an increased risk of UTI, for both treatment options.
%U http://www.la-press.com/urinary-excretion-of-phenolic-acids-by-infants-and-children-a-randomis-article-a3294